Two Cases of Crohn's Disease with Myelodysplastic Syndrome

Myelodysplastic syndromes (MDS) are bone marrow stem cell disorders characterized by dysplastic hematopoiesis leading to peripheral pancytopenias, and by a high risk of progression to acute myeloid leukemia. Several immunological disorders, particularly relapsing polychondritis, seronegative arthritis and cutaneous vasculitis have been described in association with MDS. Crohn's disease is an inflammatory bowel disease characterized by inflammatory, ulcerative bowel lesions and frequent association with systemic manifestations. Recently, some researchers have suggested that an association may exist between MDS and inflammatory bowel diseases, especially Cronh's disease, based on concomittant findigns of both disorders in some reported patients. We report here two cases who developed MDS and Crohn's disease concurrently, and review previously reported literatures.ope