뇌경색 환자들에서 무증상 관상동맥질환과 CHADS2/CHA2DS2-VASC scores와의 연관성

Dept. of Medicine/석사Background: CHADS2 and CHA2DS2-VASc scores are measurement tools that stratify thromboembolic risk in patients with nonvalvular atrial fibrillation, and are predictive of cerebral atherosclerosis, fatal stroke, and ischaemic heart disease. Patients with higher CHADS2/CHA2DS2-VASc scores are more likely to have had an akinetic/hypokinetic left ventricular segment, or a recent myocardial infarction, all of which are associated with coronary artery disease (CAD). Most of the CHADS2 score components are also risk factors for atherosclerosis. Thus, CHADS2 / CHA2DS2-VASc scores may be predictive of CAD. Methods: We enrolled 1733 consecutive patients with acute ischaemic stroke who underwent multi-slice computed tomography coronary angiography. We investigated the association of CHADS2 and CHA2DS2-VASc scores with the presence and severity of CAD. Results: Among 1733 patients, 1220 patients (70.4%) had any degree of CAD, ?50% stenosis in at least one coronary artery). As the CHADS2 and CHA2DS2-VASc scores increased, the presence of CAD also increased (p<0.001). The severity of CAD was correlated with CHADS2 (Spearman coefficient 0.229, p<0.001) and CHA2DS2-VASc scores (Spearman coefficient 0.261, p