한국 여성에서 APOA5-1131C 대립유전자형의 당뇨병 위험증가에 대한 기여도: 혈중 중성지방 농도와 관련하여

Graduate Program in Science for Aging/박사[한글] [영문]Background and objective: APOA5-1131C allele is associated with higher plasma triglyceride concentration and contributes to higher cardiovascular disease (CVD) risk in Koreans. Hypertriglyceridemia is not only a classical risk factor for CVD but also one of the commonly recognized lipid abnormalities in diabetes mellitus (DM), furthermore it is an independent risk factor for atherosclerosis in type 2 DM. Therefore, our study aimed to investigate the association of APOA5-1131T>C and the relative risk of DM in Korean, and their relationship with plasma lipid profile in Korean.Design and methods: Totally 3450 unrelated Korean women were included in this study [healthy control, n=2033; diabetes mellitus (DM), n=304, and metabolic abnormality (MA) (metabolic syndrome or impaired fasting glucose), n=1113]. Association of APOA5-1131T>C and DM risk were calculated by logistic regression analysis (odds ratio, OR; 95%confidence interval, CI) with adjustment for compounding factors. Differences in basic characteristics and biochemical parameters among groups were tested by one-way analysis of variance (ANOVA) followed by Bonferroni method with adjustment or notResults: The frequency of APOA5-1131C allele is higher in DM patients than non diabetic subjects. C carriers showed significantly higher risk of DM than TT genotype [OR0 1.39 (95% CI, 1.09?1.77), P=0.008] and the significance of the association still remained after the adjustment for age, BMI, menopause, smoking and drinking [OR1 1.61 (95% CI, 1.23-2.10), P<0.001]. Particularly, CC genotype showed a much higher increased risk of DM than TT genotype [OR0 1.93 (95% CI, 1.27-2.92), P=0.002, OR1 2.35 (95% CI, 1.46-3.77), P