Comparative observations between serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in acute viral hepatitis

의학과/석사[한글] [영문] Transaminase is the enzyme that catalyze the reversible transfer of an alpha amino group from an amino acid to an alpha keto acid. This enzyme was first discovered by Braunstein and Kritzman in 1937 in pigeon breast muscle. Although a large number of substrate-specifio transaminases have been demonstrated in various animal tissues, only two have been described in the serum, glutamic oxaloacetic transaminase(SGOT) and glutamic pyruvic transaminase(SGOT). Since the valuable significance of determination of serum transaminase levels as so called liver function test in clinical fields was introduced, many review articles have been published in the past years. The author clinically compared of SGOT and SGPT in 140 patients with acute viral hepatitis who were admitted to the department of pediatrics and of internal medicine at Severance Hospital and confirmed the fact that in acute viral hepatitis, the measurement of SGPT alterations has been found to be a useful tool in the diagnosis and study and appears to be more sensitive than SGOT.restrictio