(The) effects of porous replamineform hydroxyapatite on the regeneration of the alveolar bone in the periodontally involved extraction sockets in dogs

치의학과/석사[한글]치주질환치료의 궁극적인 목적은 상실된 치주조직의 재생과 기능회복에 있으며, 치조골결손부를 수복하기 위해서 다양한 할성골이식재가 사응되어졌다. 이 중 porous replamine form hydroxyapatite는 자연골과 구조적, 화학적인 유사성을 갖고 있어 생체 적합성이 좋고, 골형성 유도능력이 있다고 해서 광범위하게 연구되어 치조골결손부에 널리 이용되고 있다. 븐 연구의 목적은 porous replamineform hydroxyapatite를 치주진환이환 발치와와 건강한 발치와에 이식한 후 치조골의 재생과 치유에 미치는 영향에 있어 차이가 있나를 알아보기 위함이다. 이를 위해 성견의 우측 소구치에 외과적 치조골결손부를 형성한 후 교정용 탄성사를 결찰하여 만성치주염을 유발시킨 후 8주 경과후, 각 치아를 발치하여 po rousreplamineform hydroxyapatite(Interpore 200**(R))를 건강한 발치와내에 이식한 경우를 대조군으로, 치주질환이환 발치와내에 이식한 경우를 실험군으로 설정하여, 술후 2, 8, 12주의 치유결과를 조직학적으로 비교관찰하여 다음과 같은 결과를 얻었다. 1. 치조골능 상부 결합조직내의 염증세포 침윤은 대조군과 실험군 모두에서 2주에는 중증도 관찰되었으나, 8주. 12주에는 거의 소실되었다. 2. 이식재료주위의 염증세포 침윤은 대조군과 실험군에서 2, 8, 12주 모두 거의 관찰되지 않았다. 3. 이식재료 주변의 신생골 형성은 대조군과 실험군에서 2주부터 발치와의 측벽과 기저부로부터 신생골주가 자라 들어오기 시작하여 8주, 12주에는 치조골능부위를 제외한 발치와의 대부분에서 신생골이 형성되었으며, 12주에는 부분적으로 성숙골로 대체되기 시작되었다. 4. 이식재료들은 대조군과 실험군 모두에서 발치와내에 그대로 유지되었으며. 치조골의 협측과 설측에서 흡수는 관찰되지 않았다. 5. 이식재료 주변의 다핵거대세포는 대조군과 실험군 모두에서 8주부터 관찰되기 시작하였다. [영문]Regeneration of the periodontal tissue destroyed by periodontal disease is one of the final goals of periodontal therapy. In the past few years, periodontists have used various alloplastic graIning materials in an attempt to regenerate bone lost from periodontal disease. Among these materials, porous replamineform hydroxyapatite is one of the most widely used implant material, because it has been shown to be nontoxic biologically compatible with surrounding host tissue and chemically similar to bone. The purpose of this study was to evaluate whether the effects of porous replamineform hydroxyapatite on the regeneration of the alveolar bone between fresh extraction socket and periodontally invoIced extraction socket are differant. Experimental periodontitis was induced by the ligation of orthodontic elastic threads after surgically creating periodontal defect on premolars of right side of 6 adult dogs for 8 weeks. Thereafter, following the extraction of each teeth porous replamineform hydroxyapatite was inserted in extraction sockets. Control group was fresh extraction sockets with hydroxyapatite, and experimental group was periodontally involved extraction sockets with hydroxyapatite. Thereafter, dogs were sacrificed at 2, 8. 12 weeks, and the specimens were prepared and stained Hematoxyin Eosin stain for the light microscopic evaluation. The results of this study were as follow. 1. In the aspects of the inflammtory cell infiltration in subepithelial connective tissue, control and experimental group showed moderate aggregation at 2 weeks. But It desappeared at 5, 12 weeks in both groups. 2. Lack of inflammatory response associated with porous replamineform hydroxyapatite particle was seen at 2, 8, 12 weeks in both groups. 3. New bone was formed at socket wall and socket base from 2 weeks. At 8,12 weeks bone regeneration was more extensive than 2 weeks, most of the implanted porous hydroxyapatite particles encased in new bone while those in the coronal part of socket were surrounded by connective tissue. At 12 weeks lamellar bone was partly replaced. There were no differances between groups. 4. In both control and experimental group, most of the implanted porous hydroxyapatite particles remained within the extraction socket, and resorption of buccal and lingual plate was not seen 5. Multinucleated giant cells neighboring implanted porous hydroxyapatite particles were seen from 8 weeks in both groups.restrictio