The highly polarized nature of epithelial cells in exocrine glands necessitates targeting, assembly into complexes and confinement of the molecules comprising the Ca2+ signaling apparatus, to cellular microdomains. Such high degree of polarized localization has been shown for all Ca2+ signaling molecules tested, including G protein coupled receptors and their associated proteins, Ca2+ pumps, Ca2+ influx channels at the plasma membrane and Ca2+ release channels in the endoplasmic reticulum. Although the physiological significance of polarized Ca2+ signaling is clear, little is known about the mechanism of targeting, assembly and retention of Ca2+ signaling complexes in cellular microdomains. The present review attempts to summarize the evide...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the ...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Polarized expression of signaling complexes requires mechanisms for delivery, assembly and retention...
The development of the calcium signalling field, from its early beginnings some 40 years ago to the ...
The development of the calcium signalling field, from its early beginnings some 40 years ago to the ...
Ca2+ is now firmly established as the most important intracellular regulator of physiological and pa...
Ca2+ is now firmly established as the most important intracellular regulator of physiological and pa...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
In the present work we examined localization and behavior of G protein-coupled receptors (GPCR) in p...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
The localization of various Ca(2+) transport and signaling proteins in secretory cells is highly res...
Polarized Ca(2+) signals in secretory epithelial cells are determined by compartmentalized localizat...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the ...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Polarized expression of signaling complexes requires mechanisms for delivery, assembly and retention...
The development of the calcium signalling field, from its early beginnings some 40 years ago to the ...
The development of the calcium signalling field, from its early beginnings some 40 years ago to the ...
Ca2+ is now firmly established as the most important intracellular regulator of physiological and pa...
Ca2+ is now firmly established as the most important intracellular regulator of physiological and pa...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
In the present work we examined localization and behavior of G protein-coupled receptors (GPCR) in p...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
In 1992, Ca2+ microdomains were shown to exist in presynaptic nerve terminals. Soon thereafter, in 1...
The localization of various Ca(2+) transport and signaling proteins in secretory cells is highly res...
Polarized Ca(2+) signals in secretory epithelial cells are determined by compartmentalized localizat...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...
Studies of Ca2+ transport pathways in exocrine gland cells have been useful, chiefly because of the ...
Ca2+-induced Ca2+ release (CICR) plays an important role in the generation of cytosolic Ca2+ signals...