A case of hepatocellular carcinoma confirmed histologically in primary biliary cirrhosis

Primary biliary cirrhosis is a chronic cholestatic autoimmune liver disease characterized by progressive bile duct injury caused by portal and periportal inflammation, resulting in fibrosis and eventual cirrhosis in a significant proportion of patients. Little is known of the incidence, survival, and risk factors of hepatocellular carcinoma in patients with primary biliary cirrhosis. We report the case of a 68-year-old male with primary biliary cirrhosis who developed hepatocellular carcinoma without hepatitis B or C virus infection. Histological analysis revealed well-differentiated hepatocellular carcinoma. He was treated successfully with percutaneous radiofrequency ablation and has regular follow-up evaluations without recurrence. This is the first case report of hepatocellular carcinoma in primary biliary cirrhosis diagnosed with a liver biopsy in Koreaope