PURPOSE: Genes of the HoxD cluster play a major role in vertebrate limb development, and changes that modify the Hoxd12 locus affect other genes also, suggesting that HoxD function is coordinated by a control mechanism involving multiple genes during limb morphogenesis. In this study, mutant phenotypes were produced by treatment of mice with a chemical mutagen, N-ethyl-N-nitrosourea (ENU). We analyzed mutant mice exhibiting the specific microdactyly phenotype and examined the genes affected. MATERIALS AND METHODS: We focused on phenotype characteristics including size, bone formation, and digit morphology of ENU-induced microdactyly mice. The expressions of several molecules were analyzed by genome-wide screening and quantitative real-time...
SummaryVertebrates have four clusters of Hox genes (HoxA, HoxB, HoxC, and HoxD). A variety of expres...
AbstractPolyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited co...
HOXD13, the homeobox-containing gene located at the most 5′ end of the HOXD cluster, plays a critica...
Purpose: Genes of the HoxD cluster play a major role in vertebrate limb development, and changes tha...
AbstractPolyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited co...
Journal ArticleMice with targeted disruptions in Hox genes have been generated to evaluate the role ...
The genetic factors underlying human limb malformations are only beginning to be understood. An unde...
AbstractHypodactyly (Hoxa13Hd) mice have a 50-bp deletion in the coding region of exon 1 of theHoxa1...
Vertebrate limb mutants are a valuable source of information on how the vertebrate limb normally dev...
Human synpolydactyly (SPD) is an inherited congenital limb malformation caused by mutations in the H...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
Hypodactyly (Hoxa13Hd) is a spontaneous mouse mutation affecting the limbs and urogenital system. Ho...
Hypodactyly (Hoxa13Hd) is a spontaneous mouse mutation affecting the limbs and urogenital system. Ho...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
SummaryVertebrates have four clusters of Hox genes (HoxA, HoxB, HoxC, and HoxD). A variety of expres...
AbstractPolyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited co...
HOXD13, the homeobox-containing gene located at the most 5′ end of the HOXD cluster, plays a critica...
Purpose: Genes of the HoxD cluster play a major role in vertebrate limb development, and changes tha...
AbstractPolyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited co...
Journal ArticleMice with targeted disruptions in Hox genes have been generated to evaluate the role ...
The genetic factors underlying human limb malformations are only beginning to be understood. An unde...
AbstractHypodactyly (Hoxa13Hd) mice have a 50-bp deletion in the coding region of exon 1 of theHoxa1...
Vertebrate limb mutants are a valuable source of information on how the vertebrate limb normally dev...
Human synpolydactyly (SPD) is an inherited congenital limb malformation caused by mutations in the H...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
Hypodactyly (Hoxa13Hd) is a spontaneous mouse mutation affecting the limbs and urogenital system. Ho...
Hypodactyly (Hoxa13Hd) is a spontaneous mouse mutation affecting the limbs and urogenital system. Ho...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
Polyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited congenital...
SummaryVertebrates have four clusters of Hox genes (HoxA, HoxB, HoxC, and HoxD). A variety of expres...
AbstractPolyalanine expansion in the human HOXD13 gene induces synpolydactyly (SPD), an inherited co...
HOXD13, the homeobox-containing gene located at the most 5′ end of the HOXD cluster, plays a critica...