Macrophages characterized as M2 and M2-like regulate immune responses associated with immune suppression and healing; however, the relationship of this macrophage subset to CD169+ tissue-resident macrophages and their contribution to shaping alloimmune responses is unknown. Here we identified a population of M2-like tissue-resident macrophages that express high levels of the phosphatidylserine receptor TIM-4 and CD169 (TIM-4hiCD169+). Labeling and tracking of TIM-4hiCD169+ macrophages in mice revealed that this population is a major subset of tissue-resident macrophages, homes to draining LNs following oxidative stress, exhibits an immunoregulatory and hypostimulatory phenotype that is maintained after migration to secondary lymphoid organs...
Cardiovascular disease is the leading cause of death in the United States accounting for approximate...
Classically defined as defensive cells, macrophages are now known to be endowed with tissue-specifi...
Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the compo...
SummaryThe T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here...
TIM4 has previously been associated with antitumor immunity, yet the pattern of expression and the f...
UnlabelledHepatic ischemia-reperfusion injury (IRI), an innate immunity-driven inflammation response...
Phagocytes, including macrophages, recognize phosphatidylserine exposed on apoptotic cells as an “ea...
T cell Ig domain and mucin domain (TIM)-3 has previously been established as a central regulator of ...
Macrophage accumulation in transplanted organs has long been recognized as a feature of allograft re...
Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified...
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immuno...
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the...
Recent research has shown that reparative (alternatively activated or M2) macrophages play a role in...
Macrophages have been at the heart of immune research for over a century and are an integral compone...
SummaryCardiac macrophages are crucial for tissue repair after cardiac injury but are not well chara...
Cardiovascular disease is the leading cause of death in the United States accounting for approximate...
Classically defined as defensive cells, macrophages are now known to be endowed with tissue-specifi...
Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the compo...
SummaryThe T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here...
TIM4 has previously been associated with antitumor immunity, yet the pattern of expression and the f...
UnlabelledHepatic ischemia-reperfusion injury (IRI), an innate immunity-driven inflammation response...
Phagocytes, including macrophages, recognize phosphatidylserine exposed on apoptotic cells as an “ea...
T cell Ig domain and mucin domain (TIM)-3 has previously been established as a central regulator of ...
Macrophage accumulation in transplanted organs has long been recognized as a feature of allograft re...
Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified...
Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immuno...
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the...
Recent research has shown that reparative (alternatively activated or M2) macrophages play a role in...
Macrophages have been at the heart of immune research for over a century and are an integral compone...
SummaryCardiac macrophages are crucial for tissue repair after cardiac injury but are not well chara...
Cardiovascular disease is the leading cause of death in the United States accounting for approximate...
Classically defined as defensive cells, macrophages are now known to be endowed with tissue-specifi...
Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the compo...