Cancer stem cells (CSCs) play a pivotal role in cancer relapse or metastasis. We investigated the CSC-suppressing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and the relevant mechanisms in colorectal cancer. We measured the effect of NSAIDs on CSC populations in Caco-2 or SW620 cells using colosphere formation and flow cytometric analysis of PROM1 (CD133)+CD44+ cells after indomethacin treatment with/without prostaglandin E2 (PGE2) or peroxisome proliferator-activated receptor γ (PPARG) antagonist, and examined the effect of indomethacin on transcriptional activity and protein expression of NOTCH/HES1 and PPARG. These effects of indomethacin were also evaluated in a xenograft mouse model. NSAIDs (indomethacin, sulindac and aspir...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
Conclusions and Summary Colorectal cancer (CRC) is the third most common type of cancer worldwide. T...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Dept. of Medicine/박사Cancer stem cell (CSC) model assumes that a small subset of cells in tumors have...
Context Colorectal cancer is the second most common cause of cancer-related mortality in the west. T...
Colorectal cancer is one of the most common malignancies in the world. Clinical evidence suggests th...
Colorectal cancer is one of the most common Malignancies in the world. Clinical evidence suggests th...
AbstractPPARδ was identified as a target of APC through the analysis of global gene expression profi...
In this review, we discuss the available experimental evidences supporting the chemopreventive effic...
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammato...
There is a wealth of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent colorec...
Epidemiological data suggest that Non Steroidal Anti Inflammatory Drugs (NSAIDs) and Cyclooxygenase ...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known for treating inflammatory di...
[[abstract]]To determine the role of 14-3-3 in colorectal cancer apoptosis induced by nonsteroidal a...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
Conclusions and Summary Colorectal cancer (CRC) is the third most common type of cancer worldwide. T...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Dept. of Medicine/박사Cancer stem cell (CSC) model assumes that a small subset of cells in tumors have...
Context Colorectal cancer is the second most common cause of cancer-related mortality in the west. T...
Colorectal cancer is one of the most common malignancies in the world. Clinical evidence suggests th...
Colorectal cancer is one of the most common Malignancies in the world. Clinical evidence suggests th...
AbstractPPARδ was identified as a target of APC through the analysis of global gene expression profi...
In this review, we discuss the available experimental evidences supporting the chemopreventive effic...
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammato...
There is a wealth of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent colorec...
Epidemiological data suggest that Non Steroidal Anti Inflammatory Drugs (NSAIDs) and Cyclooxygenase ...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known for treating inflammatory di...
[[abstract]]To determine the role of 14-3-3 in colorectal cancer apoptosis induced by nonsteroidal a...
Chronic intake of non steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk o...
Conclusions and Summary Colorectal cancer (CRC) is the third most common type of cancer worldwide. T...
Epidemiological studies have found that long-term use of non-steroidal anti-inflammatory drugs (NSAI...