Interval growth of probably benign breast lesions on follow-up ultrasound: how can these be managed?

OBJECTIVES: To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. METHODS: By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. RESULTS: Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and