The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have focused on a few genes, proteins, or cell types. With the development of "omic"-technologies and computational analysis methods, attempts to analyze and understand complex system dynamics are now feasible. However, the decomposition of transcriptomic data sets generated from complete organs remains a major challenge. Here, we combined Weighted Gene Coexpression Network Analysis (WGCNA) and Digital Cell Quantifier (DCQ) to analyze time-resolved mouse splenic transcriptomes in acute and chronic Lymphocytic Choriomeningitis ...
Mice infected with viruses develop long-lasting high frequency memory CD8+ T cell pools, but much le...
Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individ...
CD4+ T -cell activity, including major histocompatibility class II (MHC II) responses, is vital for ...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic viru...
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic viru...
A hallmark of chronic infections is the presence of exhausted CD8 T cells, characterized by a distin...
Abstract Acute infection and chronic infection are the two most common fates of pathogenic virus inf...
Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks r...
Infection of mice with lymphocytic choriomeningitis virus (LCMV) is frequently used to study the und...
Mice infected with viruses develop long-lasting high frequency memory CD8+ T cell pools, but much le...
Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individ...
CD4+ T -cell activity, including major histocompatibility class II (MHC II) responses, is vital for ...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The host immune response against infection requires the coordinated action of many diverse cell subs...
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic viru...
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic viru...
A hallmark of chronic infections is the presence of exhausted CD8 T cells, characterized by a distin...
Abstract Acute infection and chronic infection are the two most common fates of pathogenic virus inf...
Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks r...
Infection of mice with lymphocytic choriomeningitis virus (LCMV) is frequently used to study the und...
Mice infected with viruses develop long-lasting high frequency memory CD8+ T cell pools, but much le...
Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individ...
CD4+ T -cell activity, including major histocompatibility class II (MHC II) responses, is vital for ...