Group I metabotropic glutamate receptors (mGluRs) mediate a range of signaling and plasticity processes in the brain and are of growing importance as potential therapeutic targets in clinical trials for neuropsychiatric and neurodevelopmental disorders (NDDs). Fundamental knowledge regarding the functional effects of mGluRs upon pyramidal neurons and interneurons is derived largely from rodent brain, and their effects upon human neurons are predominantly untested. We therefore addressed how group I mGluRs affect microcircuits in human neocortex. We show that activation of group I mGluRs elicits action potential firing in Martinotti cells, which leads to increased synaptic inhibition onto neighboring neurons. Some other interneurons, includi...
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluR...
The release of GABA in synapses is modulated by presynaptic metabotropic glutamate receptors (mGluRs...
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuron...
Group I metabotropic glutamate receptors (mGluRs) mediate a range of signaling and plasticity proces...
Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological ...
Diverse neocortical GABAergic neurons specialize in synaptic targeting and their effects are modulat...
In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs ...
<div><p>In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergi...
Striatal parvalbumin-containing fast-spiking (FS) interneurons provide a powerful feedforward GABAer...
In the recent past, evidence accumulated in favour of a central role of group I metabotropic glutama...
The neocortex is a layered, modular structure on the surface of the mammalian brain, which together ...
SummaryReliable activation of inhibitory pathways is essential for maintaining the balance between e...
Although metabotropic glutamate receptors (mGluRs) have been proposed to play a role in corticostria...
Reliable activation of inhibitory pathways is essential for maintaining the balance between excitati...
Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological ...
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluR...
The release of GABA in synapses is modulated by presynaptic metabotropic glutamate receptors (mGluRs...
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuron...
Group I metabotropic glutamate receptors (mGluRs) mediate a range of signaling and plasticity proces...
Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological ...
Diverse neocortical GABAergic neurons specialize in synaptic targeting and their effects are modulat...
In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs ...
<div><p>In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergi...
Striatal parvalbumin-containing fast-spiking (FS) interneurons provide a powerful feedforward GABAer...
In the recent past, evidence accumulated in favour of a central role of group I metabotropic glutama...
The neocortex is a layered, modular structure on the surface of the mammalian brain, which together ...
SummaryReliable activation of inhibitory pathways is essential for maintaining the balance between e...
Although metabotropic glutamate receptors (mGluRs) have been proposed to play a role in corticostria...
Reliable activation of inhibitory pathways is essential for maintaining the balance between excitati...
Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological ...
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluR...
The release of GABA in synapses is modulated by presynaptic metabotropic glutamate receptors (mGluRs...
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuron...