Formation of new blood vessels by differentiated endothelial tip cells, stalk cells, and phalanx cells during angiogenesis is an energy-demanding process. How these specialized endothelial cell phenotypes generate their energy, and whether there are differences between these phenotypes, is unknown. This may be key to understand their functions, as (1) metabolic pathways are essentially involved in the regulation of angiogenesis, and (2) a metabolic switch has been associated with angiogenic endothelial cell differentiation. With the use of Seahorse flux analyses, we studied metabolic pathways in tip cell and non-tip cell human umbilical vein endothelial cell populations. Our study shows that both tip cells and non-tip cells use glycolysis a...
Angiogenesis has traditionally been viewed from the perspective of how endothelial cells (ECs) coord...
Blood vessels ensure nutrient and oxygen supply to all cells via transport through the endothelium. ...
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to co...
Formation of new blood vessels by differentiated endothelial tip cells, stalk cells, and phalanx cel...
During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-existing vasc...
During vessel sprouting, endothelial "tip" cells migrate at the forefront, while the endothelial "st...
While the important and varied roles that vascular cells play in both health and disease is well rec...
Arteries and veins are lined by non-proliferating endothelial cells that play a critical role in reg...
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels supplying vit...
Endothelial cell (EC) metabolism is important for health and disease. Metabolic pathways, such as gl...
Vessel sprouting by endothelial cells (ECs) during angiogenesis relies on a navigating tip cell and ...
Recently, endothelial cell metabolism has emerged as an essential driver and regulator of both blood...
Angiogenesis has been traditionally studied by focusing on growth factors and other proangiogenic si...
The growth of new blood vessels (angiogenesis) is a bio-energetically demanding process. Surprisingl...
Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular...
Angiogenesis has traditionally been viewed from the perspective of how endothelial cells (ECs) coord...
Blood vessels ensure nutrient and oxygen supply to all cells via transport through the endothelium. ...
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to co...
Formation of new blood vessels by differentiated endothelial tip cells, stalk cells, and phalanx cel...
During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-existing vasc...
During vessel sprouting, endothelial "tip" cells migrate at the forefront, while the endothelial "st...
While the important and varied roles that vascular cells play in both health and disease is well rec...
Arteries and veins are lined by non-proliferating endothelial cells that play a critical role in reg...
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels supplying vit...
Endothelial cell (EC) metabolism is important for health and disease. Metabolic pathways, such as gl...
Vessel sprouting by endothelial cells (ECs) during angiogenesis relies on a navigating tip cell and ...
Recently, endothelial cell metabolism has emerged as an essential driver and regulator of both blood...
Angiogenesis has been traditionally studied by focusing on growth factors and other proangiogenic si...
The growth of new blood vessels (angiogenesis) is a bio-energetically demanding process. Surprisingl...
Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular...
Angiogenesis has traditionally been viewed from the perspective of how endothelial cells (ECs) coord...
Blood vessels ensure nutrient and oxygen supply to all cells via transport through the endothelium. ...
During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to co...