Evidences suggest that omega-3 fatty acid (n-3 PUFA) metabolism is imbalanced in apolipoprotein E epsilon 4 isoform carriers (APOE4). This study aimed to investigate APOE genotype-dependant modulation of FA profiles, protein and enzyme important to fatty acid (FA) metabolism in the adipose tissue, the liver and the plasma using human APOE-targeted replacement mouse-model (N=37). FA transport (FATP) and binding (FABP) protein levels in tissues and concentrations of liver carnitine palmitoyltransferase 1 (CPT1) were performed. N-3 PUFA concentration was >45% lower in the adipose tissue and liver of APOE4 mice compared to APOE3 mice. In APOE4 mice, there were higher levels of FATP and FABP in the liver and higher FATP in the adipose tissue com...
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associat...
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions betw...
Transgenic mice (Tg) overexpressing human apolipoprotein D (H-apoD) in the brain are resistant to ne...
The Apolipoprotein E (APOE) gene encodes for three isoforms in the human population (APOE2, APOE3, a...
Objectives: Omega-3 polyunsaturated fatty acid (ω-3 PUFA) metabolism seems to be disrupted in carri...
We investigated the independent and interactive impact of the common APOE genotype and marine n-3 po...
Apolipoprotein E (apoE), a key protein in lipid metabolism, is highly expressed in adipose tissues. ...
Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates...
Scope: Of the three human apolipoprotein E (APOE) alleles, the ε 3 allele is most common, which may ...
Carrying at least one apolipoprotein E ε4 allele (E4+) is the main genetic risk factor for Alzheimer...
Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates ...
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipop...
Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte tr...
none6siApolipoprotein E (apoE) is a major lipid carrier of the lipoprotein transport system that pla...
Lipid metabolic disorder occurs when ApoE gene is deficient. However, the role of Docosahexaenoic ac...
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associat...
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions betw...
Transgenic mice (Tg) overexpressing human apolipoprotein D (H-apoD) in the brain are resistant to ne...
The Apolipoprotein E (APOE) gene encodes for three isoforms in the human population (APOE2, APOE3, a...
Objectives: Omega-3 polyunsaturated fatty acid (ω-3 PUFA) metabolism seems to be disrupted in carri...
We investigated the independent and interactive impact of the common APOE genotype and marine n-3 po...
Apolipoprotein E (apoE), a key protein in lipid metabolism, is highly expressed in adipose tissues. ...
Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates...
Scope: Of the three human apolipoprotein E (APOE) alleles, the ε 3 allele is most common, which may ...
Carrying at least one apolipoprotein E ε4 allele (E4+) is the main genetic risk factor for Alzheimer...
Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates ...
Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipop...
Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte tr...
none6siApolipoprotein E (apoE) is a major lipid carrier of the lipoprotein transport system that pla...
Lipid metabolic disorder occurs when ApoE gene is deficient. However, the role of Docosahexaenoic ac...
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associat...
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions betw...
Transgenic mice (Tg) overexpressing human apolipoprotein D (H-apoD) in the brain are resistant to ne...