Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein. Annexin A2 possesses a nuclear export sequence (NES) and inhibition of the NES is sufficient to cause nuclear accumulation. Here we show that annexin A2 accumulates in the nucleus in response to genotoxic agents including gamma-radiation, UV radiation, etoposide and chromium VI and that this event is mediated by the nuclear export sequence of annexin A2. Nuclear accumulation of annexin A2 is blocked by the antioxidant agent N-acetyl cysteine (NAC) and stimulated by hydrogen peroxide (H2O2), suggesting that this is a reactive oxygen s...
AbstractAnnexin II is a growth-regulated gene, whose expression is significantly increased in variou...
AbstractEngulfment of apoptotic cells requires presentation of new cell surface ligands by the dying...
<p>TIME annexin A2 shRNA2 and scramble (control) cells were plated on microscope cover slips and inc...
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma memb...
<div><p>Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and pla...
BACKGROUND: Annexin II heavy chain (also called p36, calpactin I) is lost in prostate cancers and in...
<p>TIME cells were not treated (NT) or treated with: (A) 1.5 J/m<sup>2</sup> UV-A (365 nm) (UV), 10 ...
Hydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-depe...
Annexin A11 is a ubiquitously expressed member of the annexin family of Ca2+-dependent phospholipid ...
Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation a...
AbstractWe have screened a human cDNA expression library in λgt11 for clones encoding Alu-binding pr...
<p>(A) TIME ANXA2 shRNA1, TIME ANXA2 shRNA2 or TIME ANXA2 scramble cells were treated with 10 Gy IR ...
<p>(A) TIME cells were not treated (NT) or treated with 5 Gy IR for the times indicated. Cells were ...
Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the...
Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgrou...
AbstractAnnexin II is a growth-regulated gene, whose expression is significantly increased in variou...
AbstractEngulfment of apoptotic cells requires presentation of new cell surface ligands by the dying...
<p>TIME annexin A2 shRNA2 and scramble (control) cells were plated on microscope cover slips and inc...
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma memb...
<div><p>Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and pla...
BACKGROUND: Annexin II heavy chain (also called p36, calpactin I) is lost in prostate cancers and in...
<p>TIME cells were not treated (NT) or treated with: (A) 1.5 J/m<sup>2</sup> UV-A (365 nm) (UV), 10 ...
Hydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-depe...
Annexin A11 is a ubiquitously expressed member of the annexin family of Ca2+-dependent phospholipid ...
Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation a...
AbstractWe have screened a human cDNA expression library in λgt11 for clones encoding Alu-binding pr...
<p>(A) TIME ANXA2 shRNA1, TIME ANXA2 shRNA2 or TIME ANXA2 scramble cells were treated with 10 Gy IR ...
<p>(A) TIME cells were not treated (NT) or treated with 5 Gy IR for the times indicated. Cells were ...
Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the...
Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgrou...
AbstractAnnexin II is a growth-regulated gene, whose expression is significantly increased in variou...
AbstractEngulfment of apoptotic cells requires presentation of new cell surface ligands by the dying...
<p>TIME annexin A2 shRNA2 and scramble (control) cells were plated on microscope cover slips and inc...