Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting the disease progression. In the past few years, several studies have evidenced that lack of proper functionality of glial cells (astrocytes, microglia and oligodendrocytes) has a key role in the pathology of several neurodegenerative conditions including Alzheimer´s disease, amyotrophic lateral sclerosis and multiple sclerosis among others. However, this glial dysfunction is poorly modelled by available animal models, and we hypothesize that patientderived cells can serve as a better platform where to study this glial d...
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) ...
The cellular and molecular bases of neurological diseases have been studied for decades; however, th...
Studying human brain development and disorders is very challenging. In the absence of comparable mod...
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully...
Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolve...
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effecti...
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s...
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully ...
Neurodegenerative diseases are being modelled in-vitro using human patient-specific, induced pluripo...
The research on neurodegenerative disorders has long focused on neuronal pathology and used transgen...
Most neurodegenerative disorders have complex and still unresolved pathology characterized by progre...
Human pluripotent stem cells (hPSCs) are an attractive tool for the study of different neurodegenera...
Neurodegenerative diseases are progressive degenerative conditions characterized by the functional d...
Multiple system atrophy (MSA) is a rare neurodegenerative disease with a fatal outcome. Nowadays, on...
Neurological diseases, including dementias such as Alzheimer\u27s disease (AD) and fronto-temporal d...
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) ...
The cellular and molecular bases of neurological diseases have been studied for decades; however, th...
Studying human brain development and disorders is very challenging. In the absence of comparable mod...
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully...
Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolve...
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effecti...
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s...
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully ...
Neurodegenerative diseases are being modelled in-vitro using human patient-specific, induced pluripo...
The research on neurodegenerative disorders has long focused on neuronal pathology and used transgen...
Most neurodegenerative disorders have complex and still unresolved pathology characterized by progre...
Human pluripotent stem cells (hPSCs) are an attractive tool for the study of different neurodegenera...
Neurodegenerative diseases are progressive degenerative conditions characterized by the functional d...
Multiple system atrophy (MSA) is a rare neurodegenerative disease with a fatal outcome. Nowadays, on...
Neurological diseases, including dementias such as Alzheimer\u27s disease (AD) and fronto-temporal d...
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) ...
The cellular and molecular bases of neurological diseases have been studied for decades; however, th...
Studying human brain development and disorders is very challenging. In the absence of comparable mod...