Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels
- Jacob, Aude
- Hartz, Anika MS
- Potin, Sophie
- Coumoul, Xavier
- Yousif, Salah
- Scherrmann, Jean-Michel
- Bauer, Björn
- Declèves, Xavier
Publication date
January 2011
DOI Publisher
Springer Science and Business Media LLCAbstract
International audienceBackground: AhR activates the transcription of several target genes including CYP1B1. Recently, we showed CYP1B1 as the major cytochrome P450 (CYP) enzyme expressed in human brain microvessels. Here, we studied the effect of AhR activation by environmental pollutants on the expression of Cyp1b1 in rat brain microvessels
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