A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring A, N6 and ring C truncated analogs), was evaluated in MTS cytotoxicity assays against the human colon cancer cell lines, HCT-116 and Caco-2. In general, the C1 position of ring A is tolerant of alkoxy substituents as well as a benzoyl ester functionality. Other modifications evaluated resulted in a decrease in cytotoxic activity. The most potent compounds identified had IC50 values in the range 23–38 μM, comparable to the known cytotoxic agent, etoposide
Activation of apoptosis in cancer cells could stop the development of several cancers. Through testi...
Novel heteroatom-incorporated antofine and cryptopleurine analogs were designed, synthesized, and te...
Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (...
A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring ...
Genus of Alseodaphne has been known as a source of apoprhine alkaloid that displayed potent cytotoxi...
4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotox...
Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline...
AbstractSarcophine-diol (SD), a structural modifications of sarcophine, has shown chemopreventive ef...
4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATB...
Cancer is a disease of uncontrolled cell growth and proliferation that is predicted to directly affe...
CITATION: Harmse, L., et al. 2015. Aberrant apoptotic response of colorectal cancer cells to novel n...
To determine the target of the recently identified lead compound NSC130362 that is responsible for i...
Various E-ring hydroxylated antofine and cryptopleurine analogs were designed, synthesized, and test...
A novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole (HAC-Y6) demo...
N6-isopentenyladenosine (i6A), a member of the cytokinin family of plant hormones, has potent in vit...
Activation of apoptosis in cancer cells could stop the development of several cancers. Through testi...
Novel heteroatom-incorporated antofine and cryptopleurine analogs were designed, synthesized, and te...
Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (...
A series of synthetic aporphine derivatives structurally related to domesticine and nantenine (ring ...
Genus of Alseodaphne has been known as a source of apoprhine alkaloid that displayed potent cytotoxi...
4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotox...
Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline...
AbstractSarcophine-diol (SD), a structural modifications of sarcophine, has shown chemopreventive ef...
4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATB...
Cancer is a disease of uncontrolled cell growth and proliferation that is predicted to directly affe...
CITATION: Harmse, L., et al. 2015. Aberrant apoptotic response of colorectal cancer cells to novel n...
To determine the target of the recently identified lead compound NSC130362 that is responsible for i...
Various E-ring hydroxylated antofine and cryptopleurine analogs were designed, synthesized, and test...
A novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole (HAC-Y6) demo...
N6-isopentenyladenosine (i6A), a member of the cytokinin family of plant hormones, has potent in vit...
Activation of apoptosis in cancer cells could stop the development of several cancers. Through testi...
Novel heteroatom-incorporated antofine and cryptopleurine analogs were designed, synthesized, and te...
Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (...
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