The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphetamine administration during the pretreatment phase produced progressively enhanced locomotor activity, indicating the development of behavioral sensit...
Background: Behavioral effects of stimulant drugs are influenced by non-pharmacological factors, inc...
The neurotransmitter glutamate is known to participate in both the induction and expression of locom...
Drug use is an important problem that causes many social, mental, and physical problems to millions ...
The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early onto...
xii, 263 leaves : ill. ; 29 cmThe influence of experience during brain development was investigated ...
Repeated exposure to amphetamine (AMPH) leads to the development of behavioural sensitization that c...
Two experiments were designed to assess the effect of a “novel” environment on the development of se...
The developmental remodelling of motivational systems that underlie drug dependence and addiction...
The present experiments assessed the effect of the Group II-specific metabotropic glutamate receptor...
The purpose of the current study was to determine if rat pups treated with amphetamine (AMPH) during...
Neuroscience - Vision and Functional Brain Imaging Poster SessionIntroduction: Group I metabotropic...
Addiction is a complex process in which behavioral sensitization may be an important component. Whil...
BACKGROUND: Rats emit 50kHz ultrasonic vocalizations (USVs) in response to either natural or pharmac...
Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) t...
This investigation was an analysis of the interaction of adolescent exposure to methylphenidate (MPH...
Background: Behavioral effects of stimulant drugs are influenced by non-pharmacological factors, inc...
The neurotransmitter glutamate is known to participate in both the induction and expression of locom...
Drug use is an important problem that causes many social, mental, and physical problems to millions ...
The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early onto...
xii, 263 leaves : ill. ; 29 cmThe influence of experience during brain development was investigated ...
Repeated exposure to amphetamine (AMPH) leads to the development of behavioural sensitization that c...
Two experiments were designed to assess the effect of a “novel” environment on the development of se...
The developmental remodelling of motivational systems that underlie drug dependence and addiction...
The present experiments assessed the effect of the Group II-specific metabotropic glutamate receptor...
The purpose of the current study was to determine if rat pups treated with amphetamine (AMPH) during...
Neuroscience - Vision and Functional Brain Imaging Poster SessionIntroduction: Group I metabotropic...
Addiction is a complex process in which behavioral sensitization may be an important component. Whil...
BACKGROUND: Rats emit 50kHz ultrasonic vocalizations (USVs) in response to either natural or pharmac...
Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) t...
This investigation was an analysis of the interaction of adolescent exposure to methylphenidate (MPH...
Background: Behavioral effects of stimulant drugs are influenced by non-pharmacological factors, inc...
The neurotransmitter glutamate is known to participate in both the induction and expression of locom...
Drug use is an important problem that causes many social, mental, and physical problems to millions ...