To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8...
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome se...
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome se...
Although ~ 25% of colorectal cancer or polyp (CRC/P) cases show familial aggregation, current germli...
Colorectal cancer (CRC) is the third most common global cancer. Approximately one fifth of phenotyp...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong herit...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8...
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome se...
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome se...
Although ~ 25% of colorectal cancer or polyp (CRC/P) cases show familial aggregation, current germli...
Colorectal cancer (CRC) is the third most common global cancer. Approximately one fifth of phenotyp...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong herit...
BackgroundPrevious genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) ...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) a...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8...