Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in the pathogenesis of sepsis. Maresins have protective and resolving effects in experimental models of infection. In the present study, we investigated the effects of maresin 1 (MaR1) on mitochondrial function in cecal ligation and puncture (CLP)-induced sepsis and sepsis patients to identify mechanisms underlying maresin 1-mediated stimulation of ROS in mitochondria. We found that treatment with MaR1 significantly inhibited production of cytokines, decreased bacterial load in the peritoneal lavage fluid, reduced the number of neutrophils, decreased lactic acid level an...
Abstract Background Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflam...
Macrophages are immune-sensing big eater phagocytic cells responsible for an innate, adaptive, and...
BACKGROUND AND PURPOSE Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructi...
Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of r...
Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert o...
Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert o...
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic in...
Sepsis-associated organ dysfunction plays a critical role in its high mortality, mainly in connectio...
<div><p>Objective</p><p>Inflammation and its resolution are central to vascular injury and repair. M...
Acute lung injury (ALI) is the most common type of organ injury in sepsis, with high morbidity and m...
Objective: Inflammation and its resolution are central to vascular injury and repair. Maresins compr...
Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao Department of Emergency Medicine, The Affilia...
ObjectivesThe purpose of this study was to test whether mitochondrial dysfunction is causative of se...
Maresin1 (MaR1) is a new docosahexaenoic acid-derived pro-resolving agent that promotes the resoluti...
Acute inflammatory responses are host-protective and normally self-limited; these responses can main...
Abstract Background Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflam...
Macrophages are immune-sensing big eater phagocytic cells responsible for an innate, adaptive, and...
BACKGROUND AND PURPOSE Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructi...
Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of r...
Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert o...
Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert o...
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic in...
Sepsis-associated organ dysfunction plays a critical role in its high mortality, mainly in connectio...
<div><p>Objective</p><p>Inflammation and its resolution are central to vascular injury and repair. M...
Acute lung injury (ALI) is the most common type of organ injury in sepsis, with high morbidity and m...
Objective: Inflammation and its resolution are central to vascular injury and repair. Maresins compr...
Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao Department of Emergency Medicine, The Affilia...
ObjectivesThe purpose of this study was to test whether mitochondrial dysfunction is causative of se...
Maresin1 (MaR1) is a new docosahexaenoic acid-derived pro-resolving agent that promotes the resoluti...
Acute inflammatory responses are host-protective and normally self-limited; these responses can main...
Abstract Background Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflam...
Macrophages are immune-sensing big eater phagocytic cells responsible for an innate, adaptive, and...
BACKGROUND AND PURPOSE Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructi...