Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study
- Mutsaerts, H.
- Mirza, S.S.
- Petr, J.
- Thomas, DL
- Cash, DM
- Bocchetta, M
- De Vita, E
- Metcalfe, A.W.S.
- Shirzadi, Z.
- Robertson, A.D.
- Tartaglia, MC
- Mitchell, S.B.
- Black, SE
- Freedman, M. (Matthew)
- Tang-Wai, D
- Keren, R
- Rogaeva, E. (Ekaterina)
- Swieten, J.C. (John) van
- Laforce, R
- Tagliavini, F
- Borroni, B. (Barbara)
- Galimberti, D. (Daniela)
- Rowe, JB
- Graff, M.J. (Maud J.L.)
- Frisoni, GB
- Finger, E
- Sorbi, S. (Sandro)
- Mendonça, A.
- Rohrer, JD
- MacIntosh, BJ
- Masellis, M
DOIAbstract
Genetic forms of frontotemporal dementia are most commonly due to mutations in three genes, C9orf72, GRN or MAPT, with presymptomatic carriers from families representing those at risk. While cerebral blood flow shows differences between frontotemporal dementia and other forms of dementia, there is limited evidence of its utility in presymptomatic stages of frontotemporal dementia. This study aimed to delineate the cerebral blood flow signature of presymptomatic, genetic frontotemporal dementia using a voxel-based approach. In the multicentre GENetic Frontotemporal dementia Initiative (GENFI) study, we investigated cross-secti
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