PENGARUH PEMBERIAN BUAH JAMBU BIJI MERAH (Psidium guajava L.) DAN PEPAYA (Carica papaya) TERHADAP KADAR GLUKOSA DARAH DAN KOLESTEROL TOTAL PENDERITA DIABETES MELLITUS TIPE 2

ABSTRACT Background: Diabetes mellitus (DM) is a metabolic disease with clinical manifestations of hyperglycemia that occurs due to abnormal insulin secretion, insulin action or both. Hyperglycemia in DM causes an increase in free radicals. Antioxidants are expected to suppress lipid peroxidase, so that lipotoxic can be prevented and cell damage due to hyperglycemia can be avoided. This study aimed to analyze the effect of giving red guava fruit (Psidium guajava L.) and papaya (Carica papaya) to blood glucose and total cholesterol levels in type 2 diabetes mellitus patients. Method: Type of research is quasi experimental with pre post-test with control group design. A total of 52 subjects were divided by simple random sampling into 4 groups: the group giving red guava 282.2 grams (P1), giving papaya 302.4 grams (P2), giving red guava and papaya 292.3 grams (P3) and the control group given mineral water (K). This study was conducted for 14 and 28 days. Data analysis using One Way Anova test followed by Post Hoc, and multivariate analysis using multiple logistic regression analysis. Results: There was a significant decrease in blood glucose (GDP and GD2JPP) and total cholesterol in each group on the 14th and 28th days significantly (p 0.05). Conclusion: Giving red guava and papaya can reduce blood glucose and total cholesterol levels of type 2 diabetes mellitus patients. Keywords: Psidium guajava L, Carica papaya, Blood Glucose, Total Cholestero