Chemical approaches toward a quantitative, systems-level understanding of protein O-GlcNAcylation signaling networks

The dynamic posttranslational modification of proteins by O-linked-b-N-acetylglucosamine (O-GlcNAcylation) plays many diverse roles in cellular physiol. and disease. Here we will describe a quant., systems-level approach for studying the function, specificity, and dynamic regulation of O-GlcNAcylation. Elucidation of the signaling networks assocd. with the O-GlcNAc modification provides new insights into its central functions and may reveal new therapeutic approaches to enable its selective modulation