Binuclear cyanido complexes containing [Pt(CN)4]2 building block: Synthesis, crystal structures, magnetic properties and anticancer activities

Five new complexes of composition [Ni(N-bishydeten)Pt(CN)4] (1), [Ni(N-bishydeten)2][Pt(CN)4] (2), [Cu (N-bishydeten)Pt(CN)4] (3), [Cu(N-bishydeten)2][Pt(CN)4] (4) and [Cd(N-bishydeten)2][Pt(CN)4] (5) {Nbishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine} have been obtained and characterized by IR and EPR spectroscopies, elemental and thermal analysis and magnetic measurements. X-ray studies of 2 and 3 exhibited different structures and two different coordination modes of N-bishydeten ancillary ligand with a ratio of M:L. While N-bishydeten acts as a tetradentate with N, N0 , O and O0 atoms in a molar ratio of 1:1 formed 2,2-CT-type zigzag chain for 3, it behaves tridentate ligand by ending up with six coordinated NiII center in a complex salt by using 1:2 Mratio for 2. None of the 1 and 3 complexes produced in this study showed sufficient anticancer activity but all did exhibit apoptotic properties and one of them also performed low cytotoxic activity against cell tested.TUBITAK, Grant TBAG-104T205), The Research Foundation of Gaziosmanpas a University (Grant 2010/110) The Scientific Research Project Fund of Tunceli University (Grant MFTUB014-05