Relationship Between Blood Antioxidant Enzyme Levels And Genotype During Migraine Attack And Initial Periods in Migraine Patients.

Abstract and figures Objective: In recent years, researchers have been focused on the importance of oxidative stress on migraine pathogenesis. We aimed to investigate the roles of Superoxide Dismutase (SOD), Glutathione Peroxidase (GSH-Px), Catalase (CAT), antioxidant Glutathione (GSH) and Malondialdehyde (MDA) of a lipid peroxidation product in migraine pathogenesis. Furthermore, we also aimed to investigate the incidence of the gene polymorphisms of these enzymes in Turkish population. Material and Methods: GSH-Px, CAT, SOD activities and plasma MDA and blood GSH levels were measured in 40 migraine patients at attack and initial period and 40 healthy subjects. The genotype characteristics were determined by PCR-based RFLP method using DNA extracted from peripheral blood. Results: Statistically significant decrease in GSH-Px, CAT, SOD activities and GSH levels were found in the migraine patients compared to the control group (GSH, CAT p<0.001; GSH-Px, SOD p