Amphiphilic Dendrimers based on Polymers Dendrons

Polymeric macromolecules have a new class emerging named Dendrimers. These are highly branched and monodispersed materials comprising of three different elements i.e. core, branches and terminal groups. They have an ability of entrapping or conjugating bioactive agents by host-guest interactions and covalent bonding. Due to this distinctive property they have wide range of applications in biomedical and industrial field. Owing to their toxicity problems, the usage of these macromolecules in biological systems is restricted. Recently, Janus amphiphilic dendrimers, a novel division of dendrimers have captivated much importance in pharmaceutical and biomedical areas because of their unique characteristics and structures. Taking these into consideration, the present review has been divided into two parts. The first part has focused on various methods of dendrimer synthesis, drug delivery and targeting. The second half of the review focused on the amphiphilic dendrimers in terms of their synthesis, properties and applications along with future research for clinical applications to resolve health related issues. The objective of this research was the synthesis of JDs up to third generation through divergent method of synthesis. The produced generations hold polyester dendrons as a backbone for the purpose of drug loading. The anhydride of 5-Methyl-2-phenyl-1,3-dioxane-5-carboxylic acid was the main building block of the whole synthesis process. The third generation dendrimers were synthesized successfully. All the main products were produced in decent yield and were isolated by IR and NMR spectroscopic techniques