Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions
- Saleheen, Danish
- Zhao, Wei
- Young, Robin
- Nelson, Christopher P.
- Ho, WeangKee
- Ferguson, Jane F.
- Rasheed, Asif
- Ou, Kristy
- Nurnberg, Sylvia T.
- Bauer, Robert C.
- Goel, Anuj
- Do, Ron
- Stewart, Alexandre F. R.
- Hartiala, Jaana
- Zhang, Weihua
- Thorleifsson, Gudmar
- Strawbridge, Rona J.
- Sinisalo, Juha
- Kanoni, Stavroula
- Sedaghat, Sanaz
- Marouli, Eirini
- Kristiansson, Kati
- Zhao, Jing Hua
- Scott, Robert
- Gauguier, Dominique
- Shah, Svati H.
- Smith, Albert Vernon
- van Zuydam, Natalie
- Cox, Amanda J.
- Willenborg, Christina
- Kessler, Thorsten
- Zeng, Lingyao
- Province, Michael A.
- Ganna, Andrea
- Lind, Lars
- Pedersen, Nancy L.
- White, Charles C.
- Joensuu, Anni
- Kleber, Marcus Edi
- Hall, Alistair S.
- Maerz, Winfried
- Salomaa, Veikko
- O'Donnell, Christopher
- Ingelsson, Erik
- Feitosa, Mary F.
- Erdmann, Jeanette
- Bowden, Donald W.
- Palmer, Colin N. A.
- Gudnason, Vilmundur
- Perola, Markus
- PROMIS
- Cardiogramplusc4D
DOIAbstract
BACKGROUND: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. METHODS: We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk. We also studied 5 loci associated with smoking behavior. Study-specific gene-smoking interaction effects were calculated and pooled using fixed-effec...
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