Exposure to famine in early life and the risk of obesity in adulthood in Qingdao : Evidence from the 1959-1961 Chinese famine

Background and aims: We aimed to evaluate the association between famine exposure during early life and obesity and obesity(max) (obese at the highest weight) in adulthood. Methods and results: Data were from two population-based cross-sectional surveys conducted in 2006 and 2009 in Qingdao, China. A total of 8185 subjects born between 1/1/1941 and 12/31/1971 were categorized into unexposed (born between 01/01/1962 and 12/31/1971), fetal/ infant exposed (born between 01/01/1959 and 12/31/1961), childhood exposed (born between 01/01/1949 and 12/31/1958) and adolescence exposed (born between 01/01/1941 and 12/31/1948) according to their age when exposed to the Chinese famine from 1959 to 1961. Obesity was defined as BMI (body mass index) >= 28.0 and obesitymax was defined as BMImax (BMI at the highest weight) >= 28.0. We compared fetal/ infant exposed, childhood exposed and adolescence exposed to the unexposed using logistic regression models to assess the effect of famine exposure on later obesity and obesitymax. Fetal/infant exposed (OR = 1.59, P <0.001), childhood exposed (OR = 1.42, P <0.01) and adolescence exposed (OR = 1.86, P