Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures

1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Candidate: Aneta Svobodová Supervisior: PharmDr. Barbora Vraníková, Ph.D. Title of Diploma Thesis: Effect of compaction pressure on the compressibility of Neusilin US2 and polyethylene glycol mixtures The liquisolid systems are modern preparations, that are capable to release a poorly soluble drug from the dosage form faster and thus increase its biovailability. The main principle of their preparation is conversion of the drug in the liquid state to a dry, non-adhesive powder with suitable flow properties allowing the subsequent formation of tablets or capsules. The aim of this diploma thesis was to determine the effect of compaction pressure on the tablets parameters (mass uniformity, height and diameter, hardness, friability, disintegration time and pycnometric density) prepared from mixtures containing different ratio of Neusilin US2 and polyethylene glycol 200. It was found that the best parameters were observed in tablets compressed using higher forces (2.0 and 2.5 kN). Compression forces of 0.5 and 1.0 kN led to the preparation of compacts with insufficient mechanical resistence. Mixture containing 60 % PEG 200 was selected as the best one as it implied the highest volues hardness..