Idiopathic arterial hypertension (IPAH) is a seldom but rigorous disorder, which relates to arteriopathy, transformation and preferentially thickening of the medial vessel layer. Moreover, altered behavior in migration and proliferation as well as resistance to apoptosis has been observed in IPAH pericytes. The molecular mechanisms leading to the named physiological changes are still sparingly researched. To explore the possible cause of seen pathology, we extracted pericytes from IPAH- and healthy donor lung tissue and did a gene analysis using a microarray. The test showed that the expression of PDK-4, an enzyme involved in the regulation of glucose metabolism, was highly upregulated. We hypothesized that the observed behavioral changes i...
Poly(ADP-ribosyl)ation reactions are of interest in recent years and they take place in DNA repair i...
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the rol...
Ovarian carcinoma afflicts over 22,000 women each year with a 5 year survival rate of only 18% for s...
Idiopathic arterial hypertension (IPAH) is a seldom but rigorous disorder, which relates to arteriop...
Modelling and simulation (M&S) techniques can support characterisation and understanding of pharmaco...
Most chronic skin diseases are accompanied by a deficient skin barrier function and basic therapeuti...
Tese de doutoramento, Ciências Biomédicas (Ciências Biopatológicas), Universidade de Lisboa, Faculda...
Die Bluthirnschranke (BHS) hindert toxische und schädliche Substanzen zum Gehirn zu gelangen, stellt...
Phagozyten entfernen apoptotische Zellen während der Entwicklung und beseitigen Pathogene im Immunsy...
Rett Syndrome (RS) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene on...
Um sich in einer Vielzahl von Wirten vermehren zu können, haben sich Herpesviren im Laufe ihrer Evo...
As an enabling technology, Structural Health Monitoring (SHM) assesses the state of mechanical struc...
(Oberflächen-) Gewässer weltweit sind mit geringen Mengen (ng/L bis wenige µg/L) humaner Pharmazeuti...
Coronin 1 is one of seven mammalian coronin family members that is preferentially expressed in hemat...
Inflammation is known to lead to long-term changes in the responsiveness to subsequent inflammator...
Poly(ADP-ribosyl)ation reactions are of interest in recent years and they take place in DNA repair i...
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the rol...
Ovarian carcinoma afflicts over 22,000 women each year with a 5 year survival rate of only 18% for s...
Idiopathic arterial hypertension (IPAH) is a seldom but rigorous disorder, which relates to arteriop...
Modelling and simulation (M&S) techniques can support characterisation and understanding of pharmaco...
Most chronic skin diseases are accompanied by a deficient skin barrier function and basic therapeuti...
Tese de doutoramento, Ciências Biomédicas (Ciências Biopatológicas), Universidade de Lisboa, Faculda...
Die Bluthirnschranke (BHS) hindert toxische und schädliche Substanzen zum Gehirn zu gelangen, stellt...
Phagozyten entfernen apoptotische Zellen während der Entwicklung und beseitigen Pathogene im Immunsy...
Rett Syndrome (RS) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene on...
Um sich in einer Vielzahl von Wirten vermehren zu können, haben sich Herpesviren im Laufe ihrer Evo...
As an enabling technology, Structural Health Monitoring (SHM) assesses the state of mechanical struc...
(Oberflächen-) Gewässer weltweit sind mit geringen Mengen (ng/L bis wenige µg/L) humaner Pharmazeuti...
Coronin 1 is one of seven mammalian coronin family members that is preferentially expressed in hemat...
Inflammation is known to lead to long-term changes in the responsiveness to subsequent inflammator...
Poly(ADP-ribosyl)ation reactions are of interest in recent years and they take place in DNA repair i...
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the rol...
Ovarian carcinoma afflicts over 22,000 women each year with a 5 year survival rate of only 18% for s...