Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 μm field of view and 5 μm transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe is 3.3 mm diameter and 20 mm rigid length, thus enabling passage through the endoscopic channel. The scanner has 1.8 kHz resonant frequency, and each volumetric acquisition takes 0.17 s with 2 volumes∕s display. 3D-OCT and angiography imaging of the colon was performed during surveillance colonoscopy.National Institutes of Health (U.S.) (Grant F32-CA183400)National Institutes of Health (U.S.) (Grant R01-CA075289)National Institutes of Health (U.S.) (Grant R01-CA178636)National Institutes of Health (U.S.) (Grant R01- EY011289)National Institutes of Health (U.S.) (Grant R44-CA101067)Air Force Office of Scientific Research (Grant FA9550-12-1-0499)Air Force Office of Scientific Research (Grant FA9550-15-1-0473