The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers. Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on “chromatin-state” to explain their interplay. Integrating eQTL, mRNA co-expression, and Hi-C data analysis, we developed a computational method to infer causal enhancer-gene interactions,...
The definitive version of this Open Access article was published by PLoS ONE 6(11): e27513. doi:10.1...
Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Vario...
A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to ...
The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has ...
Enhancers are cis-acting non-coding regulatory elements that regulate the transcriptional output of ...
The human genome contains regulatory elements, such as enhancers, that are often rewired by cancer c...
Enhancers are short regulatory regions (50-1500 bp) of DNA that control the tissue-specific activati...
The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Her...
Whole genome analysis approaches are revealing recurrent cancer-associated somatic alterations in no...
Motivation: Reversible epigenetic modifications that happen on the DNA’s histones, namely histone mo...
We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer ...
Transposable elements (TEs) are repetitive DNA elements that have an autonomous capability of replic...
Abstract Spatiotemporal patterns of gene expression depend on enhancer elements and other factors d...
Enhancers are cis regulatory elements that play key roles in the control of cell-type specific gene ...
BACKGROUND: Several mechanisms involved in gene regulation are altered in cancer. Cataloging these a...
The definitive version of this Open Access article was published by PLoS ONE 6(11): e27513. doi:10.1...
Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Vario...
A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to ...
The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has ...
Enhancers are cis-acting non-coding regulatory elements that regulate the transcriptional output of ...
The human genome contains regulatory elements, such as enhancers, that are often rewired by cancer c...
Enhancers are short regulatory regions (50-1500 bp) of DNA that control the tissue-specific activati...
The growth of human cancer cells is driven by aberrant enhancer and gene transcription activity. Her...
Whole genome analysis approaches are revealing recurrent cancer-associated somatic alterations in no...
Motivation: Reversible epigenetic modifications that happen on the DNA’s histones, namely histone mo...
We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer ...
Transposable elements (TEs) are repetitive DNA elements that have an autonomous capability of replic...
Abstract Spatiotemporal patterns of gene expression depend on enhancer elements and other factors d...
Enhancers are cis regulatory elements that play key roles in the control of cell-type specific gene ...
BACKGROUND: Several mechanisms involved in gene regulation are altered in cancer. Cataloging these a...
The definitive version of this Open Access article was published by PLoS ONE 6(11): e27513. doi:10.1...
Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Vario...
A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to ...