Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Pathogenesis and therapy of complement-mediated kidney disease in a mouse model

Lesher, Allison M

January 2013

The complement system is a branch of innate immunity tasked with aiding in the recognition and elimi...

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin

O'Flynn, Joseph
van der Pol, Pieter
Dixon, Karen O.
Prohászka, Zoltán
Daha, Mohamed R.

January 2016

Previous studies have shown that complement activation on renal tubular cells is involved in the in...

Properdin:emerging roles of a pattern-recognition molecule

Kemper, Claudia
Atkinson, John P
Hourcade, Dennis E

April 2010

Complement is an innate immune system that is a first line of defense against pathogens and facilita...

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Michels, Marloes A. H. M.
van de Kar, Nicole C. A. J.
van den Bos, Ramon M.
van der Velden, Thea J. A. M.
van Kraaij, Sanne A. W.
Sarlea, Sebastian A.
Gracchi, Valentina
Oosterveld, Michiel J. S.
Volokhina, Elena B.
van den Heuvel, Lambertus P. W. J.

June 2019

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by pre...

The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Michels, M.A.H.M.
Volokhina, E.B.
Kar, N.C.A.J. van de
Heuvel, L.P.W.J. van den

January 2019

Contains fulltext : 206807.pdf (publisher's version ) (Open Access

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

Paixao Cavalcante, Danielle
López-Trascasa, Margarita
Skattum, Lillemor
Giclas, Patricia C
Goodship, Timothy H
de Córdoba, Santiago Rodríguez
Truedsson, Lennart
Morgan, Bryan Paul
Harris, Claire Louise

C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the alte...

Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease

O'Flynn, Joseph
Kotimaa, Juha
Faber-Krol, Ria
Koekkoek, Karin
Klar-Mohamad, Ngaisah
Koudijs, Angela
Schwaeble, Wilhelm J.
Stover, Cordula
Daha, Mohamed R.
van Kooten, Cees

December 2018

Properdin is the only known positive regulator of complement activation by stabilizing the alternati...

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

August 2020

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activatio...

Role of properdin in complement-mediated kidney diseases

van Essen, Mieke F.
Ruben, Jurjen M.
de Vries, Aiko P. J.
van Kooten, Cees

May 2019

As part of the innate immune system, the complement system is an important mechanism in our first li...

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

Zaferani, Azadeh
Vives, Romain R.
van der Pol, Pieter
Hakvoort, Jelleke J.
Navis, Gerjan J.
van Goor, Harry
Daha, Mohamed R.
Lortat-Jacob, Hugues
Seelen, Marc A.
van den Born, Jacob

February 2011

Properdin binds to proximal tubular epithelial cells (PTEC) and activates the complement system via ...

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

Diana Pauly
Benedikt M Nagel
Jörg Reinders
Tobias Killian
Matthias Wulf
Susanne Ackermann
Boris Ehrenstein
Peter F Zipfel
Christine Skerka
Bernhard H F Weber

The complement system is an essential part of the innate immune system by acting as a first line of ...

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples

Diana Pauly (170378)
Benedikt M. Nagel (559462)
Jörg Reinders (559463)
Tobias Killian (559464)
Matthias Wulf (559465)
Susanne Ackermann (559466)
Boris Ehrenstein (559467)
Peter F. Zipfel (105431)
Christine Skerka (105424)
Bernhard H. F. Weber (162289)

May 2014

<div><p>The complement system is an essential part of the innate immune system by acting as a first ...

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Sjogren, A.K.
Breitholtz, K.
Ahlberg, E.
Milton, L.
Forsgard, M.
Persson, M.
Stahl, S.H.
Wilmer, M.J.G.
Hornberg, J.J.

January 2018

Contains fulltext : 196765.pdf (publisher's version ) (Closed access)Drug-induced ...

Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease.

Zaferani, Azadeh
Vivès, Romain R
Van Der Pol, Pieter
Hakvoort, Jelleke J
Navis, Gerjan J
Van Goor, Harry
Daha, Mohamed R
Lortat-Jacob, Hugues
Seelen, Marc A
Van Den Born, Jacob

February 2011

International audienceProperdin binds to proximal tubular epithelial cells (PTEC) and activates the ...

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects

Diana Pauly
Benedikt M. Nagel
Tobias Killian
Matthias Wulf
Susanne Ackermann
Boris Ehrenstein
Peter F. Zipfel
Christine Skerka
Bernhard H. F. Weber

September 2016

The complement system is an essential part of the innate immune system by acting as a first line of ...

Pathogenesis and therapy of complement-mediated kidney disease in a mouse model

Lesher, Allison M

January 2013

The complement system is a branch of innate immunity tasked with aiding in the recognition and elimi...

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin

O'Flynn, Joseph
van der Pol, Pieter
Dixon, Karen O.
Prohászka, Zoltán
Daha, Mohamed R.

January 2016

Previous studies have shown that complement activation on renal tubular cells is involved in the in...

Properdin:emerging roles of a pattern-recognition molecule

Kemper, Claudia
Atkinson, John P
Hourcade, Dennis E

April 2010

Complement is an innate immune system that is a first line of defense against pathogens and facilita...

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Michels, Marloes A. H. M.
van de Kar, Nicole C. A. J.
van den Bos, Ramon M.
van der Velden, Thea J. A. M.
van Kraaij, Sanne A. W.
Sarlea, Sebastian A.
Gracchi, Valentina
Oosterveld, Michiel J. S.
Volokhina, Elena B.
van den Heuvel, Lambertus P. W. J.

June 2019

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by pre...

The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Michels, M.A.H.M.
Volokhina, E.B.
Kar, N.C.A.J. van de
Heuvel, L.P.W.J. van den

January 2019

Contains fulltext : 206807.pdf (publisher's version ) (Open Access

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

Paixao Cavalcante, Danielle
López-Trascasa, Margarita
Skattum, Lillemor
Giclas, Patricia C
Goodship, Timothy H
de Córdoba, Santiago Rodríguez
Truedsson, Lennart
Morgan, Bryan Paul
Harris, Claire Louise

C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the alte...

Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease

O'Flynn, Joseph
Kotimaa, Juha
Faber-Krol, Ria
Koekkoek, Karin
Klar-Mohamad, Ngaisah
Koudijs, Angela
Schwaeble, Wilhelm J.
Stover, Cordula
Daha, Mohamed R.
van Kooten, Cees

December 2018

Properdin is the only known positive regulator of complement activation by stabilizing the alternati...

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

August 2020

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activatio...

Role of properdin in complement-mediated kidney diseases

van Essen, Mieke F.
Ruben, Jurjen M.
de Vries, Aiko P. J.
van Kooten, Cees

May 2019

As part of the innate immune system, the complement system is an important mechanism in our first li...

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

Zaferani, Azadeh
Vives, Romain R.
van der Pol, Pieter
Hakvoort, Jelleke J.
Navis, Gerjan J.
van Goor, Harry
Daha, Mohamed R.
Lortat-Jacob, Hugues
Seelen, Marc A.
van den Born, Jacob

February 2011

Properdin binds to proximal tubular epithelial cells (PTEC) and activates the complement system via ...

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

Diana Pauly
Benedikt M Nagel
Jörg Reinders
Tobias Killian
Matthias Wulf
Susanne Ackermann
Boris Ehrenstein
Peter F Zipfel
Christine Skerka
Bernhard H F Weber

The complement system is an essential part of the innate immune system by acting as a first line of ...

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples

Diana Pauly (170378)
Benedikt M. Nagel (559462)
Jörg Reinders (559463)
Tobias Killian (559464)
Matthias Wulf (559465)
Susanne Ackermann (559466)
Boris Ehrenstein (559467)
Peter F. Zipfel (105431)
Christine Skerka (105424)
Bernhard H. F. Weber (162289)

May 2014

<div><p>The complement system is an essential part of the innate immune system by acting as a first ...

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Sjogren, A.K.
Breitholtz, K.
Ahlberg, E.
Milton, L.
Forsgard, M.
Persson, M.
Stahl, S.H.
Wilmer, M.J.G.
Hornberg, J.J.

January 2018

Contains fulltext : 196765.pdf (publisher's version ) (Closed access)Drug-induced ...

Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease.

Zaferani, Azadeh
Vivès, Romain R
Van Der Pol, Pieter
Hakvoort, Jelleke J
Navis, Gerjan J
Van Goor, Harry
Daha, Mohamed R
Lortat-Jacob, Hugues
Seelen, Marc A
Van Den Born, Jacob

February 2011

International audienceProperdin binds to proximal tubular epithelial cells (PTEC) and activates the ...

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects

Diana Pauly
Benedikt M. Nagel
Tobias Killian
Matthias Wulf
Susanne Ackermann
Boris Ehrenstein
Peter F. Zipfel
Christine Skerka
Bernhard H. F. Weber

September 2016

The complement system is an essential part of the innate immune system by acting as a first line of ...

Pathogenesis and therapy of complement-mediated kidney disease in a mouse model

Lesher, Allison M

January 2013

The complement system is a branch of innate immunity tasked with aiding in the recognition and elimi...

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin

O'Flynn, Joseph
van der Pol, Pieter
Dixon, Karen O.
Prohászka, Zoltán
Daha, Mohamed R.

January 2016

Previous studies have shown that complement activation on renal tubular cells is involved in the in...

Properdin:emerging roles of a pattern-recognition molecule

Kemper, Claudia
Atkinson, John P
Hourcade, Dennis E

April 2010

Complement is an innate immune system that is a first line of defense against pathogens and facilita...

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Abstract

Extracted data

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Abstract

Extracted data

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