Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice.
- Neunkirchner, A.
- Kratzer, B.
- Köhler, C.
- Smole, U.
- Mager, L.
- Schmetterer, K.
- Trapin, D.
- Leb-Reichl, V.
- Rosloniec, E.
- Naumann, R.
- Kenner, L.
- Jahn-Schmid, B.
- Bohle, B.
- Valenta, R.
- Pickl, W.
DOIAbstract
Immunoglobulin(Ig)E-associated allergies result from misguided immune responses against innocuous antigens. CD4+ T lymphocytes are critical for initiating and perpetuating that process, yet the crucial factors determining whether an individual becomes sensitized towards a given allergen remain largely unknown
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