Aspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent clinical and preclinical evidence suggests that ASP may also exert psychoactive effects. It remains unclear whether ASP has antidepressant-like activity, and any molecular mechanisms underlying such activity have yet to be elucidated. Using the forced swimming test (FST), a well-established animal model of depression widely used to screen potential antidepressants in rodents, we investigated the effects of subacute treatment with ASP (0, 6, 12, 25, and 50 mg/kg, i.p.) on immobility in the FST, and on FST-induced changes in endocrine and immune parameters in rats, in comparison to the clinical antidepressants imipramine (IMI) and fluoxetine (FLU...
The antidepressant-induced reduction in immobility time in the forced swimming test may depend on me...
Dipyrone is an analgesic-antipyretic drug with especially COX-3 inhibition on central prostaglandin ...
Increasing evidence is now demonstrating the involvement of the immune system and in particular of t...
Aspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent cl...
Aspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent cl...
Background: Many studies have indicated that inflammation and depression are associated with each ot...
Background: Depression was seen to be associated with an increased level of inflammatory biomarkers ...
The forced swimming test (FST) is a behavioral screen for antidepressant drugs. It consists of placi...
Evidence has accumulated suggesting that major depression is associated with dysfunction of inflamma...
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens ...
Oxidative stress disturbances have been reported in depressed patients and in animals submitted to s...
Background: There is evidence, that statins can augment the antidepressant effects of fluoxetine in ...
Current treatments for depression are inadequate for many patients, and different therapies have bee...
Environmental factors play a key role in the etiology of depression. The rodent forced swim test (FS...
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed...
The antidepressant-induced reduction in immobility time in the forced swimming test may depend on me...
Dipyrone is an analgesic-antipyretic drug with especially COX-3 inhibition on central prostaglandin ...
Increasing evidence is now demonstrating the involvement of the immune system and in particular of t...
Aspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent cl...
Aspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent cl...
Background: Many studies have indicated that inflammation and depression are associated with each ot...
Background: Depression was seen to be associated with an increased level of inflammatory biomarkers ...
The forced swimming test (FST) is a behavioral screen for antidepressant drugs. It consists of placi...
Evidence has accumulated suggesting that major depression is associated with dysfunction of inflamma...
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens ...
Oxidative stress disturbances have been reported in depressed patients and in animals submitted to s...
Background: There is evidence, that statins can augment the antidepressant effects of fluoxetine in ...
Current treatments for depression are inadequate for many patients, and different therapies have bee...
Environmental factors play a key role in the etiology of depression. The rodent forced swim test (FS...
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed...
The antidepressant-induced reduction in immobility time in the forced swimming test may depend on me...
Dipyrone is an analgesic-antipyretic drug with especially COX-3 inhibition on central prostaglandin ...
Increasing evidence is now demonstrating the involvement of the immune system and in particular of t...