Add to ORKGOur previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-responsive-element-binding protein (CREB) signal system may be involved in the molecular mechanism of depression. The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats. Fluoxetine was administrated to either naive rats or stressed rats for 21 days. The results showed that chronic forced swim stress induced depressive-like behaviors and decreased the levels of P-ERK2, P-CREB, ERK1/2 and CREB in hippocampus and prefrontal cortex. Fluoxetine alleviated the depressive-like behaviors and reversed the disruptions of the P-ERK2 and P-CREB in stressed rats. F...
Converging evidence points to adaptive changes in neuroplasticity and gene expression as mediators o...
AbstractThe purpose of this study is to investigate the expression of major potassium channel subtyp...
Objective Dysfunction of neural plasticity in the brain is known to alter neural networks, resulting...
Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-resp...
Our recent research demonstrates that the extracellular signal-regulated kinase (ERK) signal pathway...
Accumulating evidence indicates that antidepressants alter intracellular signalling mechanisms resul...
Exposure of an organism to chronic social isolation (CSIS) has been shown to have an important role ...
Background: Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfu...
Regulation of gene expression is purported as a major component in the long-term action of antidepre...
Plastic response and successful adaptation to stress are of particular importance in the hippocampus...
Introduction: Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. ...
Background. Fluoxetine (FLU) is the first-line and widely used medication for depression; however, F...
Chronic social isolation (CSIS)–induced alternation in synaptic and mitochondrial function of specif...
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the d...
The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure durin...
Converging evidence points to adaptive changes in neuroplasticity and gene expression as mediators o...
AbstractThe purpose of this study is to investigate the expression of major potassium channel subtyp...
Objective Dysfunction of neural plasticity in the brain is known to alter neural networks, resulting...
Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic AMP-resp...
Our recent research demonstrates that the extracellular signal-regulated kinase (ERK) signal pathway...
Accumulating evidence indicates that antidepressants alter intracellular signalling mechanisms resul...
Exposure of an organism to chronic social isolation (CSIS) has been shown to have an important role ...
Background: Psychological stress, particularly in chronic form, can lead to mood and cognitive dysfu...
Regulation of gene expression is purported as a major component in the long-term action of antidepre...
Plastic response and successful adaptation to stress are of particular importance in the hippocampus...
Introduction: Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. ...
Background. Fluoxetine (FLU) is the first-line and widely used medication for depression; however, F...
Chronic social isolation (CSIS)–induced alternation in synaptic and mitochondrial function of specif...
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the d...
The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure durin...
Converging evidence points to adaptive changes in neuroplasticity and gene expression as mediators o...
AbstractThe purpose of this study is to investigate the expression of major potassium channel subtyp...
Objective Dysfunction of neural plasticity in the brain is known to alter neural networks, resulting...