The effects of long-term exposure of primary cultured rat dorsal root ganglion (DRG) cells to bradykinin (BK), compared to short-term exposure, were investigated to establish whether BK could induce prostaglandin E2 (PGE2) release from DRG cells. Short-term exposure (30 min) resulted in a small but significant amount of PGE2 release which was mainly inhibited by a selective COX-1 inhibitor, SC-560 but only partially by a selective COX-2 inhibitor, NS-398, and did not induce COX-2 protein as determined by Western blotting. In contrast, long-term exposure (3 hr) induced a large amount of PGE2 release, which was completely abolished by indomethacin or NS-398. The level of COX-2 mRNA began to be detected by ribonuclease protection assay after 3...
Isolated cells from adult rat dorsal root ganglia (DRG) are frequently used as a model system to stu...
Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing subs...
Small mammalian proteins called the prokineticins [ prokineticin 1 ( PK1) and PK2] and two correspon...
Bradykinin is an important inflammatory mediator that can either activate and/or sensitise nocicepto...
Bradykinin produced at sites of tissue injury and inflammation elicits acute pain and alters the sen...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)It is well established that dorsal root...
Local mediator prostaglandins and bradykinin are involved in inflammation and pain. We explored brad...
Prostaglandins are known to enhance the inflammatory and nociceptive actions of other chemical media...
The perception of pain - burning, aching and soreness - acts as a physiological warning that protect...
TRPV1 ion channels have crucial roles in inflammatory hyperalgesia as TRPV1-/- mice show reduced the...
Prostaglandin E2 (PGE2) is a chemical mediator of nociception that can evoke characteristic pain beh...
Bradykinin-induced formation of [3H]inositol-l,4,5 trisphosphate ([3H]IP3) in cultured neonatal rat ...
The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. ...
The whole-cell patch-clamp technique was used to record Ba2+ currents through voltage-activated calc...
Background Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclo...
Isolated cells from adult rat dorsal root ganglia (DRG) are frequently used as a model system to stu...
Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing subs...
Small mammalian proteins called the prokineticins [ prokineticin 1 ( PK1) and PK2] and two correspon...
Bradykinin is an important inflammatory mediator that can either activate and/or sensitise nocicepto...
Bradykinin produced at sites of tissue injury and inflammation elicits acute pain and alters the sen...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)It is well established that dorsal root...
Local mediator prostaglandins and bradykinin are involved in inflammation and pain. We explored brad...
Prostaglandins are known to enhance the inflammatory and nociceptive actions of other chemical media...
The perception of pain - burning, aching and soreness - acts as a physiological warning that protect...
TRPV1 ion channels have crucial roles in inflammatory hyperalgesia as TRPV1-/- mice show reduced the...
Prostaglandin E2 (PGE2) is a chemical mediator of nociception that can evoke characteristic pain beh...
Bradykinin-induced formation of [3H]inositol-l,4,5 trisphosphate ([3H]IP3) in cultured neonatal rat ...
The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. ...
The whole-cell patch-clamp technique was used to record Ba2+ currents through voltage-activated calc...
Background Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclo...
Isolated cells from adult rat dorsal root ganglia (DRG) are frequently used as a model system to stu...
Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing subs...
Small mammalian proteins called the prokineticins [ prokineticin 1 ( PK1) and PK2] and two correspon...