Ureteric bud branching and nephrogenesis are performed through large-scale proliferation and apoptosis events during renal development. Reactive oxygen species (ROS), produced by NADPH oxidase, may contribute to cell behaviors, including proliferation and apoptosis. We investigated the role of NADPH oxidase expression and ROS production in developing kidneys. Immunohistochemistry revealed that NADPH oxidase components were expressed on epithelial cells in ureteric bud branches, as well as on immature glomerular cells and epithelial cells in nephrogenic zones. ROS production, detected by dihydroethidium assay, was strongly observed in ureteric bud branches and nephrogenic zones, corresponding with NADPH oxidase localization. Organ culture of...
AbstractThe kidney develops by cycles of ureteric bud branching and nephron formation. The cycles be...
Reactive oxygen species (ROS) influence many physiological processes including host defense, hormone...
<p>The figure shows various cytosolic and membrane components of NADPH oxidase subunits getting acti...
NADPH oxidase-derived reactive oxygen species are implicated in apoptosis in certain kidney cells. O...
Reactive oxygen species (ROS) play an important role in normal cellular physiology. They regulate di...
Production of reactive oxygen species by tubular epithelial cells in culture. Reactive oxygen specie...
<p>ROS formation quantified after staining kidney <b>(a)</b> and heart <b>(b)</b> cryosections with ...
NADPH oxidases synthesize reactive oxygen species that may participate in fibrosis progression. NOX4...
AbstractIntrarenally-produced dopamine (DA) induces a large increase in urinary sodium excretion mai...
Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases ...
International audienceAbstract Cardiovascular disease is a frequent complication inducing mortality ...
NADPH oxidase–derived excessive production of reactive oxygen species (ROS) in the kidney plays a ke...
Intrarenally-produced dopamine (DA) induces a large increase in urinary sodium excretion mainly due ...
The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an...
<p><b>A</b>, Representative images of dihydroethidium (DHE) staining (original magnification, ×100)....
AbstractThe kidney develops by cycles of ureteric bud branching and nephron formation. The cycles be...
Reactive oxygen species (ROS) influence many physiological processes including host defense, hormone...
<p>The figure shows various cytosolic and membrane components of NADPH oxidase subunits getting acti...
NADPH oxidase-derived reactive oxygen species are implicated in apoptosis in certain kidney cells. O...
Reactive oxygen species (ROS) play an important role in normal cellular physiology. They regulate di...
Production of reactive oxygen species by tubular epithelial cells in culture. Reactive oxygen specie...
<p>ROS formation quantified after staining kidney <b>(a)</b> and heart <b>(b)</b> cryosections with ...
NADPH oxidases synthesize reactive oxygen species that may participate in fibrosis progression. NOX4...
AbstractIntrarenally-produced dopamine (DA) induces a large increase in urinary sodium excretion mai...
Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases ...
International audienceAbstract Cardiovascular disease is a frequent complication inducing mortality ...
NADPH oxidase–derived excessive production of reactive oxygen species (ROS) in the kidney plays a ke...
Intrarenally-produced dopamine (DA) induces a large increase in urinary sodium excretion mainly due ...
The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an...
<p><b>A</b>, Representative images of dihydroethidium (DHE) staining (original magnification, ×100)....
AbstractThe kidney develops by cycles of ureteric bud branching and nephron formation. The cycles be...
Reactive oxygen species (ROS) influence many physiological processes including host defense, hormone...
<p>The figure shows various cytosolic and membrane components of NADPH oxidase subunits getting acti...