Principles of asymmetric synthesis / Robert E. Gawley and Jeffrey Aub©♭

pharmacy bookfair2015Includes bibliographical references and index.xii, 555 pages :Most of the molecules, in the world are chiral. Asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions.Principles of asymmetric synthesis, 2nd Edition, provides the reader with an excellent introduction by explaining the basic physical-organic principles governing stereoselective reactions, and presenting a detailed, annotated glossary of stereochemical terms. Following this introduction is a valuable critical overview of the most common methods for the preparation of enantiomerically pure compounds, and a synopsis of the various techniques used for the analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods.The authors then present and evaluate the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context.Key features:Authoritative glossary to aid understanding of stereochemical terminology.Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type.A handy reference guide to the literature of asymmetric synthesis for practitioners in the field.A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis, that have been accomplished using an asymmetric reaction as a key step. Book jacket