Joint and tendon involvement predict disease progression in systemic sclerosis : a EUSTAR prospective study
- J. Avouac
- A. Walker Ulrich
- E. Hachulla
- G. Riemekasten
- G. Cuomo
- E. Carreira Patricia
- P. Caramaschi
- P. Ananieva Lidia
- M. Matucci-Cerinic
- L. Czirjak
- C. Denton
- M. Ladner Ulf
- Y. Allanore
- S. Guiducci
- A. Tyndall
- G. Lapadula
- F. Iannone
- O. Distler
- R. Becvar
- S. Sierakowsky
- K. Bielecka Otylia
- M. Cutolo
- A. Sulli
- G. Valentini
- S. Rednic
- I. Nicoara
- G. Vlachoyiannopoulos Panayiotis
- C. Montecucco
- R. Caporali
- S. Novak
- C. Chizzolini
- J. Kucharz Eugene
- A. Kotulska
- F. Cozzi
- B. Rozman
- C. Mallia
- B. Coleiro
- A. Gabrielli
- D. Farge-Bancel
- S. Hadj-Khelifa
- P. Airò
- R. Hesselstrand
- A. Scheja
- D. Martinovic
- B. Gurman Alexandra
- Y. Braun-Moscovici
- N. Hunzelmann
- R. Pellerito
- M. Bambara Lisa
- J. Morovic-Vergles
- C. Black
- N. Damjanov
- I. Kö
- O. Santamaria Vera
- S. Heitmann
- D. Krasowska
- M. Seidel
- P. Hasler
- H. Burkhardt
- A. Himsel
- P. Da Silva José
- J. Salvador Maria
- B. Stamenkovi
- A. Stankovic
- B. Marasini
- L. Belloli
- M. Tikly
- N. Denisov Lev
- R. Scorza
- M. Engelhart
- G. Strauss
- G. Szü
- S. Szamosi
- C. De La Puente
- G. De La Peñ
- Ø
- T. Garen
- D. Launay
- G. Valesini
- V. Riccieri
- M. Ionescu Ruxandra
- D. Opris
- M. Wigley Fredrick
- V. Stoica
- M. Mihai Carmen
- J. Distler
- P. Meroni
- S. Zeni
- L. Mouthon
- V. Smith
- P. Cantatore Francesco
- A. Corrado
- S. Ullman
- L. Iversen
- R. Pozzi Maria
- K. Eyerich
- R. Hein
- J. Szechinski
- P. Wiland
- B. Krummel-Lorenz
- M. Aringer
- R. Westhovens
- E. De Langhe
- B. Anic
- M. Baresi
- M. Ü
- K. Otsa
- S. Yavuz
- C. Radominski Sebastiã
- C. De Souza Mü
- S. Jimenez
- J. Busquets
- S. Popa
- S. Agachi
- T. Zenone
- A. Mathieu
- A. Vacca
- L. Stamp
- P. Chapman
- C. Tanaseanu
- M. Popescu
- R. Foti
- R. Rubio Silvia
DOIAbstract
Objective: To determine whether joint synovitis and tendon friction rubs (TFRs) can predict the progression of systemic sclerosis (SSc) over time. Patients and methods We performed a prospective cohort study that included 1301 patients with SSc from the EUSTAR database with disease duration 643 years at inclusion and with a follow-up of at least 2 years. Presence or absence at clinical examination of synovitis and TFRs was extracted at baseline. Outcomes were skin, cardiovascular, renal and lung progression. Overall disease progression was defined according to the occurrence of at least one organ progression. Results: Joint synovitis (HR: 1.26, 95% CI 1.01 to 1.59) and TFRs (HR: 1.32, 95% CI 1.03 to 1.70) were independently predictive of o...
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