Etude des mécanismes centraux par lesquels l'étonogestrel, un progestatif de la famille des gonanes, renforce la réponse respiratoire à l'hypercapnie. Investigations réalisées dans le cadre des hypoventilations centrales

  • Loiseau, Camille
Publication date
June 2017
Publisher
HAL CCSD

Abstract

Ondine’s curse is a disease characterized by a dysfunction of the CO2/H+ chemosensitivity. Clinical observation suggest that desogestrel, a progestin of the gonane family, have induced a recovery of CO2/H+ chemosensitivity (Straus et al., 2010).This work aimed to have a better understanding of the central mechanisms by which etonogestrel (ETO, the metabolite of desogestrel) may have induced a recovery of CO2/H+ chemosensitivity. Pharmacological exposures and c-fos expression analysis were performed in parallel on ex vivo preparations of central nervous system from newborn rats.Our results indicated that ETO strengthens the respiratory response to metabolic acidosis in a range of concentration close to the clinical exposure, by a diencephali...

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