Ondine’s curse is a disease characterized by a dysfunction of the CO2/H+ chemosensitivity. Clinical observation suggest that desogestrel, a progestin of the gonane family, have induced a recovery of CO2/H+ chemosensitivity (Straus et al., 2010).This work aimed to have a better understanding of the central mechanisms by which etonogestrel (ETO, the metabolite of desogestrel) may have induced a recovery of CO2/H+ chemosensitivity. Pharmacological exposures and c-fos expression analysis were performed in parallel on ex vivo preparations of central nervous system from newborn rats.Our results indicated that ETO strengthens the respiratory response to metabolic acidosis in a range of concentration close to the clinical exposure, by a diencephali...
Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain states and ada...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
New Findings What is the central question of this study? This study was designed to investigate whet...
Ondine’s curse is a disease characterized by a dysfunction of the CO2/H+ chemosensitivity. Clinical ...
Le syndrome d'Ondine est une maladie neurorespiratoire d'origine génétique caractérisée par la réduc...
International audienceDysfunction of central respiratory CO2/H+ chemosensitivity is a pivotal factor...
International audienceCentral congenital hypoventilation syndrome (CCHS) is a neurorespiratory disea...
Ce travail doctoral est consacré aux interactions entre la commande respiratoire et le désogestrel e...
The maintenance of PCO2 and pH in arterial blood is vital. The principal mechanism through which thi...
O gás monóxido de carbono (CO) possui diversas funções no sistema nervoso central (SNC) funcionando ...
Heterozygous mutations of the transcription factor PHOX2B are responsible for Congenital Central Hyp...
Les intoxications produites par les inhibiteurs de cholinestérases (IChE) comme les composés organop...
This paper reviews the local hormone endothelin-2 (ET-2), or vasoactive intestinal contractor (VIC),...
Central chemoreception is the mechanism by which the brain regulates breathing in response to change...
Intoxications induced by cholinesterase (ChE) inhibitors (ChEIs) like organophosphorus compounds (OP...
Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain states and ada...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
New Findings What is the central question of this study? This study was designed to investigate whet...
Ondine’s curse is a disease characterized by a dysfunction of the CO2/H+ chemosensitivity. Clinical ...
Le syndrome d'Ondine est une maladie neurorespiratoire d'origine génétique caractérisée par la réduc...
International audienceDysfunction of central respiratory CO2/H+ chemosensitivity is a pivotal factor...
International audienceCentral congenital hypoventilation syndrome (CCHS) is a neurorespiratory disea...
Ce travail doctoral est consacré aux interactions entre la commande respiratoire et le désogestrel e...
The maintenance of PCO2 and pH in arterial blood is vital. The principal mechanism through which thi...
O gás monóxido de carbono (CO) possui diversas funções no sistema nervoso central (SNC) funcionando ...
Heterozygous mutations of the transcription factor PHOX2B are responsible for Congenital Central Hyp...
Les intoxications produites par les inhibiteurs de cholinestérases (IChE) comme les composés organop...
This paper reviews the local hormone endothelin-2 (ET-2), or vasoactive intestinal contractor (VIC),...
Central chemoreception is the mechanism by which the brain regulates breathing in response to change...
Intoxications induced by cholinesterase (ChE) inhibitors (ChEIs) like organophosphorus compounds (OP...
Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain states and ada...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
New Findings What is the central question of this study? This study was designed to investigate whet...