Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp²) H activation and C(sp³)-H amination
- Song, Liangliang
- Tian, Guilong
- Van der Eycken, Johan
- Van der Eycken, Erik V
DOIAbstract
A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp(2))-H activation and C(sp(3))-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance
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