Association between gait and cognition in an elderly population based sample

Background. Gait is thought to have a cognitive component, but the current evidence in healthy elderly is mixed. We studied the association between multiple gait and cognitive measures in a cohort of older people. Methods. 178 cognitively healthy participants from the Whitehall II Imaging Sub-study had a detailed clinical and neuropsychological assessment, as well as a MRI scan. Spatiotemporal and variability gait measures were derived from two 10m walks at self-selected speed. We did a linear regression analysis, entering potential confounders with backwards elimination of variables with p≥0.1.The remaining variables were then entered into a second regression before doing a stepwise analysis of cognitive measures, entering variables with p