First and highly stereoselective synthesis of both enantiomers of octahydroindole‐2‐phosphonic acid (OicP)

We report the first stereoselective synthesis of (2R,3aR,7aR)‐ and (2S,3aS,7aS)‐octahydroindole‐2‐phosphonic acid (OicP derivatives). This involves the highly diastereoselective synthesis of cis‐fused bicyclic (3aR,7aR)‐ and (3aS,7aS)‐pyrrolidin‐2‐ones via Meyers' bicyclic lactams, and the highly diastereoselective addition of trimethyl phosphite to N‐acyliminium ion intermediates.The authors thank the Consejo Nacional de Ciencia y Tecnología (CONACYT) for financial support through projects 256985, 181816 and 248868. E. I. M.-T. also thanks CONACYT for a graduate scholarship (584971).Peer reviewe