Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis

Inflammation plays a central role in the pathophysiology of acute pancreatitis (AP). We hypothesized that changes in the function of key components of the inflammatory cascade, caused by genetic polymorphisms, could determine the development and/or severity of AP. We studied the following polymorphisms in 269 patients: IL23R rs11209026, TNF rs1800629, RIPK2 rs42490, NOD2 rs9302752, MCP1 rs1024611 and NFKB1 rs28362491. The rs11209026 A allele was related to the presence of AP (p = 0.007261; OR = 1 .523). Epistasis analysis revealed that AP susceptibility was increased by interaction between IL23R rs11209026 and TNF rs1800629 (p = 1.205 x 10(-5); ORinteraction = 4.031). The rs42490-G allele was associated with an increased risk of severe pancreatitis (p = 0.01583; OR = 2.736), severe or moderately severe pancreatitis (p = 0.04206; OR = 1.609), and death (p = 0.03226; OR = 3.010). In conclusion, these results point to a plausible role for genetic polymorphisms in IL23R and RIPK2 in the development and severity of AP.This work was supported by the grants from Instituto de Salud Carlos III co-financed by the European Regional Development Fund [PI11/01386, PI16/00752, RETIC RD 06/020, RD09/0076/00165] and the Andalusian Regional Government in Spain (CTS-143). FDC received a "Ramon y Cajal" grant [RYC-2014-16458] from the Ministerio de Economia, Industria y Competitividad, Spain.Peer reviewe