An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
- Liu, J. (Jun)
- Carnero-Montoro, E. (Elena)
- Dongen, J. (Jenny) van
- Lent, S. (Samantha)
- Prokić, I. (Ivana)
- Ligthart, S. (Symen)
- Tsai, P.-C. (Pei-Chien)
- Martin, T.C. (Tiphaine C.)
- Mandaviya, P.R. (Pooja)
- Jansen, R. (Rick)
- Peters, M.A.D. (Marjolein)
- Duijts, L. (Liesbeth)
- Jaddoe, V.W.V. (Vincent)
- Tiemeier, H.W. (Henning)
- Felix, J.F. (Janine)
- Willemsen, G.A.H.M. (Gonneke)
- Geus, E.J.C. (Eco) de
- Chu, A.Y. (Audrey)
- Levy, D. (Daniel)
- Hwang, S.-J. (Shih-Jen)
- Bressler, J. (Jan)
- Gondalia, R. (Rahul)
- Salfati, E. (Elias)
- Herder, C. (Christian)
- Hidalgo, B. (Bertha)
- Tanaka, T. (Toshiko)
- Moore, A.Z. (Ann Zenobia)
- Lemaitre, R.N. (Rozenn N.)
- Jhun, M.A. (Min A.)
- Smith, J.A. (Jennifer A)
- Sotoodehnia, N. (Nona)
- Bandinelli, S. (Stefania)
- Ferrucci, L. (Luigi)
- Arnett, D.K. (Donna)
- Grallert, H. (Harald)
- Assimes, T.L. (Themistocles L.)
- Hou, L. (Lifang)
- Baccarelli, A.A. (Andrea)
- Whitsel, E.A. (Eric)
- van Dijk, K.W. (Ko Willems)
- Amin, N. (Najaf)
- Uitterlinden, A.G. (André)
- Sijbrands, E.J.G. (Eric)
- Franco, O.H. (Oscar)
- Dehghan, A. (Abbas)
- Spector, T.D. (Timothy)
- Amin, N. (Najaf)
- Hivert, M.-F. (Marie-France)
- Rotter, J.I. (Jerome I.)
- Meigs, J.B. (James)
- Palmer, C.N.A. (Colin)
- Meurs, J.B.J. (Joyce) van
- Isaacs, A.J. (Aaron)
- Boomsma, D.I. (Dorret I.)
- Bell, J.T. (Jordana T.)
- Demirkan, A. (Ayşe)
- Duijn, C.M. (Cornelia) van
DOIAbstract
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methyl...
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