Prevalence of intrauterine adhesions after the application of hyaluronic acid gel after dilatation and curettage in women with at least one previous curettage: short-term outcomes of a multicenter, prospective randomized controlled trial
- Hooker, Angelo B.
- de Leeuw, Robert
- de Ven, Peter M. Van
- Bakkum, Erica A.
- Thurkow, Andreas L.
- Vogel, Niels E. A.
- van Vliet, Huib A. A. M.
- Bongers, Marlies Y.
- Emanuel, Mark H.
- Verdonkschot, Annelies E. M.
- Brolmann, Hans A. M.
- Huirne, Judith A. F.
DOIAbstract
Objective: To examine whether intrauterine application of auto-crosslinked hyaluronic acid (ACP) gel, after dilatation and curettage (D&C), reduces the incidence of intrauterine adhesions (IUAs). Design: Multicenter; women and assessors blinded prospective randomized trial. Setting: University and university-affiliated teaching hospitals. Patient(s): A total of 152 women with a miscarriage of <14 weeks with at least one previous D&C for miscarriage or termination of pregnancy. Intervention(s): Women were randomly assigned to either D&C plus ACP gel (intervention group) or D&C alone (control group). A follow-up diagnostic hysteroscopy was scheduled 8-12 weeks after the D&C procedure. Main Outcome Measure(s): The primary outcome was the numbe...
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