Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete understanding of their regulation. Heterodimerization of RAF kinases as well as dephosphorylation of a conserved "S259" inhibitory site are important steps for RAF activation but the precise mechanisms and dynamics remain unclear. A ternary complex comprised of SHOC2, MRAS, and PP1 (SHOC2 complex) functions as a RAF S259 holophosphatase and gain-of-function mutations in SHOC2, MRAS, and PP1 that promote complex formation are found in Noonan syndrome. Here we show that SHOC2 complex-mediated S259 RAF dephosphorylation is critically required for growth factor-induced RAF heterodimerization as well as for MEK dissociation from BRAF. We also uncover ...
AbstractThe Raf/MEK/ERK pathway is a conserved signaling module controlling cell growth, proliferati...
AbstractC-Raf is a member of the Ras–Raf–MEK–ERK mitogen-activated protein kinase (MAPK) signaling p...
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell ...
Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete unde...
Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a ...
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hi...
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hi...
SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the RAS-ERK pathway, ...
Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2...
The RAS-RAF pathway is one of the most commonly dysregulated in human cancers1-3. Despite decades of...
The RAS-RAF-MAPK signaling pathway is fundamental for cell proliferation and altered in a majority ...
Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates sig...
The RAS-ERK/MAPK pathway is a critical signalling pathway regulating cell growth, proliferation, and...
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell ...
Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates sig...
AbstractThe Raf/MEK/ERK pathway is a conserved signaling module controlling cell growth, proliferati...
AbstractC-Raf is a member of the Ras–Raf–MEK–ERK mitogen-activated protein kinase (MAPK) signaling p...
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell ...
Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete unde...
Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a ...
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hi...
Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hi...
SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the RAS-ERK pathway, ...
Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2...
The RAS-RAF pathway is one of the most commonly dysregulated in human cancers1-3. Despite decades of...
The RAS-RAF-MAPK signaling pathway is fundamental for cell proliferation and altered in a majority ...
Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates sig...
The RAS-ERK/MAPK pathway is a critical signalling pathway regulating cell growth, proliferation, and...
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell ...
Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates sig...
AbstractThe Raf/MEK/ERK pathway is a conserved signaling module controlling cell growth, proliferati...
AbstractC-Raf is a member of the Ras–Raf–MEK–ERK mitogen-activated protein kinase (MAPK) signaling p...
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell ...